Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | CNR2 | P34972 | 3/20 | 0.56 |
| ▸ | GPR55 | Q9Y2T6 | 3/20 | 0.56 |
| ▸ | SHBG | P04278 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA9 | Q16790 | 2/20 | 0.52 |
| ▸ | HSD17B3 | P37058 | 2/20 | 0.52 |
| ▸ | TNF | P01375 | 1/20 | 0.52 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.52 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | GLA | P06280 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8441390 | 0.82 | KDM4E (0.63) | KDM4EMAOBCA9ALDH1A1HPGD | |
| SCHEMBL19019865 | 0.79 | KDM4E (0.53) | KDM4ECA12CA9TNFNOD2 | |
| SCHEMBL5345045 | 0.77 | MAOB (0.77) | KDM4EMAOBCA12CA9TNF | |
| SCHEMBL5346589 | 0.76 | MAOB (0.65) | KDM4EMAOBCA12CA9TNF | |
| SCHEMBL8442563 | 0.74 | HPGD (0.72) | KDM4EMAOBGAAMEN1KMT2A | |
| SCHEMBL2761835 | 0.72 | MET (0.56) | KDM4EMAOBCA12CA9TNF | |
| SCHEMBL19019871 | 0.72 | KDM4E (0.51) | KDM4ECA12CA9TNFNOD2 | |
| SCHEMBL19019924 | 0.72 | TDP1 (0.53) | KDM4EMAOBCA12CA9MAOA | |
| SCHEMBL19275311 | 0.72 | GPR55 (0.46) | KDM4ECNR2GPR55SHBGALDH1A1 | |
| SCHEMBL3575287 | 0.72 | MET (0.56) | KDM4EMAOBCA12CA9TNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985912-A | COUMARONE COMPOUNDS AS BACTERICIDES | PFIZER INC. (US) | 1999-11-16 | — | — | US | disclosed |
| US-5624951-A | 4-hydroxy coumarin derivatives with antibacterial activity | PFIZER INC. (US) | 1997-04-29 | — | — | US | disclosed |
| EP-0658158-A1 | 4-HYDROXY COUMARIN DERIVATIVES WITH ANTIBACTERIAL ACTIVITY | PFIZER INC. (US) | 1995-06-21 | — | — | EP | disclosed |
| WO-1994005649-A1 | 4-HYDROXY COUMARIN DERIVATIVES WITH ANTIBACTERIAL ACTIVITY | PFIZER INC. (US) | 1994-03-17 | — | — | WO | disclosed |