SCHEMBL8440432

SCHEMBL8440432

N#Cc1cc(N)ccc1NCC(O)CO

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GLA P06280 1/20 0.44
KDM4E B2RXH2 4/20 0.37
ALDH1A1 P00352 2/20 0.37
USP2 O75604 1/20 0.37
LMNA P02545 1/20 0.36
ADRB2 P07550 4/20 0.35
ADRB1 P08588 2/20 0.35
CYP1A2 P05177 2/20 0.35
CYP3A4 P08684 2/20 0.35
TSHR P16473 1/20 0.35
MAPK1 P28482 1/20 0.35
ADRB3 P13945 1/20 0.35
MAPT P10636 2/20 0.34
HPGD P15428 2/20 0.34
MAP3K8 P41279 1/20 0.33
KCNA5 P22460 1/20 0.33
KCNH2 Q12809 1/20 0.33
AR P10275 1/20 0.33
VDR P11473 1/20 0.33
MEN1 O00255 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8436276 0.99 GLA (0.43) GLAKDM4EALDH1A1USP2LMNA
SCHEMBL3919119 0.78 ALDH1A1 (0.41) ALDH1A1LMNACYP1A2CYP3A4TSHR
SCHEMBL8436343 0.78 KDM4E (0.41) KDM4EALDH1A1USP2LMNACYP1A2
SCHEMBL28119946 0.78 KDM4E (0.51) GLAKDM4EALDH1A1TSHRMAPT
SCHEMBL28119945 0.78 KDM4E (0.51) GLAKDM4EALDH1A1TSHRMAPT
Hydrochloric Acid SCHEMBL8438565 0.77 KDM4E (0.40) KDM4EALDH1A1USP2LMNAADRB2
SCHEMBL3863528 0.77 VDR (0.47) ALDH1A1LMNAADRB2ADRB1CYP1A2
SCHEMBL8930628 0.77 GLA (0.67) GLAKDM4EALDH1A1LMNATSHR
Hydrochloric Acid SCHEMBL3860889 0.76 VDR (0.46) ALDH1A1LMNAADRB2ADRB1CYP1A2
SCHEMBL6574847 0.76 PDE3B (0.37) CYP1A2ARVDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5865856-A MIXTURE CONTAINING COUPLER AND DEVELOPER WELLA AKTIENGESELLSCHAFT (DE) 1999-02-02 US claimed
EP-0797980-A1 Oxidation hair dye composition comprising a 2,5-diaminobenzonitrile as well as 2,5-diaminobenzonitrile compounds Wella Aktiengesellschaft (DE) 1997-10-01 EP claimed
US-5865856-A MIXTURE CONTAINING COUPLER AND DEVELOPER WELLA AKTIENGESELLSCHAFT (DE) 1999-02-02 US disclosed
EP-0797980-A1 Oxidation hair dye composition comprising a 2,5-diaminobenzonitrile as well as 2,5-diaminobenzonitrile compounds Wella Aktiengesellschaft (DE) 1997-10-01 EP disclosed