Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.51 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | LY96 | Q9Y6Y9 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8444865 | 0.92 | ABCB1 (0.43) | HDAC8ABCB1PTPN1TNFRSF1AALOX5 | |
| SCHEMBL30039059 | 0.91 | HDAC8 (0.62) | HDAC8ABCB1PTPN1TNFRSF1AMAPT | |
| SCHEMBL7775518 | 0.91 | HDAC8 (0.62) | HDAC8ABCB1PTPN1TNFRSF1AMAPT | |
| SCHEMBL20029756 | 0.91 | HDAC8 (0.52) | HDAC8ABCB1PTPN1TNFRSF1AALOX5 | |
| SCHEMBL7776748 | 0.91 | HDAC8 (0.62) | HDAC8ABCB1PTPN1TNFRSF1AMAPT | |
| SCHEMBL8444371 | 0.91 | ABCB1 (0.42) | HDAC8ABCB1PTPN1TNFRSF1AALOX5 | |
| SCHEMBL2337927 | 0.88 | AKR1C3 (0.48) | HDAC8ABCB1PTPN1TNFRSF1AALOX5 | |
| SCHEMBL2337919 | 0.88 | AKR1C3 (0.48) | HDAC8ABCB1PTPN1TNFRSF1AALOX5 | |
| SCHEMBL7776254 | 0.86 | HDAC1 (0.51) | HDAC8 | |
| SCHEMBL7776246 | 0.86 | HDAC1 (0.51) | HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2277387-A1 | New use of histone deacetylase inhibitors in changing MRJP3 protein in royal jelly | NatureWise Biotech & Medicals Corporation (TW) | 2011-01-26 | — | — | EP | disclosed |
| EP-2236503-A1 | Cinamic compounds and derivatives therefrom for the inhibition of histone deacetylase | NatureWise Biotech & Medicals Corporation (TW) | 2010-10-06 | — | — | EP | disclosed |