Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 4/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5003621 | 0.78 | MAOA (0.59) | MAOAKDM4EMAOBADORA3ADORA1 | |
| SCHEMBL4428324 | 0.75 | MAOB (0.58) | MAOAMAOBALDH1A1ADORA3ADORA1 | |
| SCHEMBL25300447 | 0.75 | LMNA (0.45) | MAOAKDM4EHSD17B10TDP1ALDH1A1 | |
| SCHEMBL29503553 | 0.75 | LMNA (0.45) | MAOAKDM4EHSD17B10TDP1ALDH1A1 | |
| SCHEMBL2304841 | 0.72 | CA12 (0.49) | MAOAKDM4EHSD17B10MAOBCRBN | |
| SCHEMBL1800952 | 0.72 | MAOB (0.49) | MAOAKDM4EHSD17B10MAOBCRBN | |
| SCHEMBL13799426 | 0.72 | MAOA (0.44) | MAOAKDM4EHSD17B10MAOBALDH1A1 | |
| SCHEMBL2253369 | 0.72 | NPC1 (0.55) | MAOAKDM4EHSD17B10TDP1MAOB | |
| SCHEMBL12452452 | 0.72 | CHRM2 (0.46) | MAOAKDM4EHSD17B10MAOBCRBN | |
| SCHEMBL8082599 | 0.72 | CHRM2 (0.46) | MAOAKDM4ETDP1MAOBCRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5968985-A | INHIBITORS OF SODIUM ION/HYDROGEN ION EXCHANGE IN CELLS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-19 | — | — | US | disclosed |
| EP-0773927-A2 | BENZOYLGUANIDINE DERIVATIVES AS MEDICAMENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996004241-A2 | BENZOYLGUANIDINE DERIVATIVES AS MEDICAMENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-02-15 | — | — | WO | disclosed |