Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.76 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.46 |
| ▸ | NOS1 | P29475 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6768501 | 0.86 | SIGMAR1 (1.00) | SIGMAR1MAPTTDP1RAB9ANPC1 | |
| SCHEMBL7681718 | 0.85 | SCN2A (0.64) | SIGMAR1MAPTTDP1RAB9ANPC1 | |
| SCHEMBL6768624 | 0.84 | SIGMAR1 (0.67) | SIGMAR1MAPTTDP1RAB9ANPC1 | |
| SCHEMBL6895611 | 0.84 | SIGMAR1 (0.58) | SIGMAR1MAPTTDP1RAB9ANPC1 | |
| SCHEMBL6770940 | 0.83 | SIGMAR1 (0.60) | SIGMAR1MAPTTDP1SCN2APOLB | |
| SCHEMBL7100143 | 0.82 | SIGMAR1 (0.58) | SIGMAR1MAPTTDP1RAB9ANPC1 | |
| SCHEMBL7104845 | 0.82 | RAB9A (0.59) | SIGMAR1MAPTTDP1RAB9ANPC1 | |
| SCHEMBL6765764 | 0.79 | SIGMAR1 (0.58) | SIGMAR1MAPTTDP1RAB9ANPC1 | |
| SCHEMBL6774554 | 0.79 | SIGMAR1 (0.87) | SIGMAR1MAPTTDP1NOTUMTSHR | |
| SCHEMBL7099375 | 0.79 | SIGMAR1 (0.65) | SIGMAR1MAPTTDP1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0925300-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-06-30 | — | — | EP | claimed |
| EP-0925300-A4 | — | — | 1999-06-30 | — | — | EP | claimed |
| WO-1997030054-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1997-08-21 | — | — | WO | claimed |