Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NOS1 | P29475 | 6/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7235549 | 0.86 | TP53 (0.53) | MEN1KMT2ATP53KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL7232145 | 0.83 | MEN1 (0.50) | MEN1KMT2ATP53KDM4EALDH1A1 | |
| SCHEMBL31262691 | 0.81 | MAP4K1 (0.55) | MCHR1HSP90AA1HSP90AB1NOS1NOS3 | |
| SCHEMBL31090988 | 0.80 | ASIC3 (0.46) | TP53KDM4EALDH1A1LMNAHSP90AA1 | |
| SCHEMBL4692515 | 0.77 | NOS1 (0.60) | NOS1NOS3 | |
| Acetic Acid SCHEMBL7772763 | 0.77 | KMT2A (0.48) | MEN1KMT2ATP53KDM4EALDH1A1 | |
| SCHEMBL3946751 | 0.76 | HSP90AA1 (0.71) | MEN1KMT2ATP53KDM4EALDH1A1 | |
| SCHEMBL3943592 | 0.75 | HSP90AA1 (0.81) | MEN1KMT2ATP53KDM4EALDH1A1 | |
| SCHEMBL8436021 | 0.75 | ELANE (0.51) | MCHR1NOS1NOS3CYP1A1CYP1B1 | |
| SCHEMBL3364095 | 0.75 | HSP90AA1 (0.55) | KDM4EALDH1A1MAPTHPGDALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958282-A1 | 2-AMINO-6-(2-SUBSTITUTED-4-PHENOXY)-SUBSTITUTED-PYRIDINES | Pfizer Products Inc. (US) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998034919-A1 | 2-AMINO-6-(2-SUBSTITUTED-4-PHENOXY)-SUBSTITUTED-PYRIDINES | PFIZER PRODUCTS INC. (US) | 1998-08-13 | — | — | WO | disclosed |