Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.30 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.30 |
| ▸ | MMP1 | P03956 | 2/20 | 0.30 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8444636 | 0.85 | — | — | |
| SCHEMBL8443404 | 0.82 | LIPG (0.33) | — | |
| SCHEMBL8444000 | 0.81 | MMP1 (0.33) | MDM4TP53MMP1GABRA1GABRB2 | |
| SCHEMBL8443556 | 0.79 | ESR1 (0.33) | MDM4TP53PSMD14COPS5MMP1 | |
| SCHEMBL8444631 | 0.76 | MDM4 (0.33) | MDM4TP53MMP1GABRA1GABRB2 | |
| SCHEMBL27981064 | 0.76 | HSPA5 (0.50) | — | |
| SCHEMBL427621 | 0.75 | — | — | |
| SCHEMBL31294224 | 0.75 | — | — | |
| SCHEMBL8442024 | 0.75 | NR1H2 (0.32) | MMP1 | |
| SCHEMBL8443608 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962435-A | ANTICHOLESTEROL AGENT | HOECHST MARION ROUSSEL, INC. (US) | 1999-10-05 | — | — | US | disclosed |
| US-5677291-A | Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols | HOECHST MARION ROUSSEL, INC. (US) | 1997-10-14 | — | — | US | disclosed |
| CN-1029615-C | Novel 2,6-Di-alkyl-4-silyl-phenols as antiatherosclerotic agents | MERRELL DOW PHARMA (US) | 1995-08-30 | — | — | CN | disclosed |
| CN-1057843-A | New 2 as antiatherosclerotic, 6-two-alkyl-4-silyl-phenols | MERRELL DOW PHARMA (US) | 1992-01-15 | — | — | CN | disclosed |