Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | HTR1D | P28221 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | IGF1R | P08069 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8442538 | 0.78 | HTR1A (0.76) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL9004457 | 0.78 | HTR1A (0.80) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8442654 | 0.78 | HTR1A (0.80) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8442467 | 0.77 | HTR1A (0.78) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8442968 | 0.76 | HTR1A (0.78) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8444529 | 0.76 | HTR1A (0.75) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8442587 | 0.76 | IGF1R (0.81) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL7699947 | 0.76 | ALDH1A1 (0.46) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8443682 | 0.76 | HTR1A (0.72) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL7777456 | 0.76 | HTR1A (0.63) | HTR1AALDH1A1KDM4ECYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0395312-B1 | Piperazine derivatives | WYETH JOHN & BROTHER LTD (GB) | 1999-05-12 | — | — | EP | claimed |