Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAMKK2 | Q96RR4 | 5/20 | 0.45 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.43 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 5/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.39 |
| ▸ | CAMKK1 | Q8N5S9 | 2/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27502447 | 0.77 | IKBKB (0.40) | BACE1ASIC3FEN1ALOX5APNOS3 | |
| SCHEMBL16581487 | 0.76 | NUDT1 (0.51) | CAMKK2BACE1NUDT1HSP90AA1CAMKK1 | |
| SCHEMBL6582620 | 0.75 | FEN1 (0.42) | ASIC3FEN1ALOX5APNOS3NOS1 | |
| SCHEMBL1068254 | 0.75 | NUDT1 (0.57) | CAMKK2BACE1NUDT1HSP90AA1CAMKK1 | |
| SCHEMBL28743148 | 0.74 | IKBKB (0.40) | ASIC3FEN1ALOX5AP | |
| SCHEMBL6583707 | 0.72 | FEN1 (0.43) | FEN1ALOX5APNOS3NOS1 | |
| SCHEMBL10589678 | 0.71 | ERN1 (0.49) | BACE1NUDT1HSP90AA1HDAC2 | |
| SCHEMBL27502061 | 0.71 | IKBKB (0.41) | ASIC3NOS3NOS1 | |
| SCHEMBL27936297 | 0.70 | NUDT1 (0.47) | CAMKK2BACE1NUDT1HSP90AA1HDAC4 | |
| Ethane SCHEMBL28278519 | 0.70 | PTPN5 (0.46) | CAMKK2BACE1NUDT1HSP90AA1FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0958282-A1 | 2-AMINO-6-(2-SUBSTITUTED-4-PHENOXY)-SUBSTITUTED-PYRIDINES | Pfizer Products Inc. (US) | 1999-11-24 | — | — | EP | disclosed |
| WO-1998034919-A1 | 2-AMINO-6-(2-SUBSTITUTED-4-PHENOXY)-SUBSTITUTED-PYRIDINES | PFIZER PRODUCTS INC. (US) | 1998-08-13 | — | — | WO | disclosed |