Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
| ▸ | TTR | P02766 | 4/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8444491 | 0.91 | TNKS (0.44) | TNKSKDM4ETTRPTPN1MAPT | |
| SCHEMBL8442828 | 0.86 | TNKS (0.46) | TNKSKMT2AKDM4EMEN1ALDH1A1 | |
| SCHEMBL8440006 | 0.82 | ALDH1A1 (0.41) | TNKSKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL8444466 | 0.81 | HDAC8 (0.42) | TNKSKMT2AKDM4EMEN1L3MBTL1 | |
| SCHEMBL8576273 | 0.81 | TMEM97 (0.40) | TNKSKMT2AKDM4EMEN1TSHR | |
| Hydrochloric Acid SCHEMBL8440657 | 0.80 | KDM4E (0.42) | KMT2AKDM4EMEN1L3MBTL1ALDH1A1 | |
| SCHEMBL27359860 | 0.80 | TNKS (0.49) | TNKSKMT2AKDM4EMEN1ATM | |
| SCHEMBL8441277 | 0.75 | MAPT (0.44) | KMT2AKDM4EMEN1GPR84ATM | |
| SCHEMBL8441434 | 0.74 | TTR (0.48) | TNKSKDM4ETTRL3MBTL1PTPN1 | |
| SCHEMBL8443666 | 0.72 | KDM4E (0.39) | KMT2AKDM4EMEN1GPR84L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5968985-A | INHIBITORS OF SODIUM ION/HYDROGEN ION EXCHANGE IN CELLS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-10-19 | — | — | US | disclosed |
| EP-0773927-A2 | BENZOYLGUANIDINE DERIVATIVES AS MEDICAMENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996004241-A2 | BENZOYLGUANIDINE DERIVATIVES AS MEDICAMENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-02-15 | — | — | WO | disclosed |