Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 9/20 | 0.54 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | MTOR | P42345 | 1/20 | 0.31 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.31 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1355355 | 0.87 | ADORA2A (0.62) | ADORA2ASCN9ASCN5AMKNK1MKNK2 | |
| SCHEMBL8444460 | 0.82 | ADORA2A (0.78) | ADORA2AHPGDMKNK1MKNK2 | |
| SCHEMBL8446498 | 0.81 | ADORA2A (0.80) | ADORA2AHPGDMKNK1MKNK2 | |
| SCHEMBL8448329 | 0.81 | ADORA2A (0.80) | ADORA2AHPGDMKNK1MKNK2 | |
| SCHEMBL1353175 | 0.80 | ADORA2A (0.64) | ADORA2ASCN9ASCN5ARXRA | |
| SCHEMBL13284352 | 0.76 | ADORA2A (0.81) | ADORA2A | |
| SCHEMBL13284350 | 0.76 | ADORA2A (0.81) | ADORA2A | |
| SCHEMBL1355537 | 0.75 | ADORA2A (0.74) | ADORA2ASCN9AKDM4E | |
| SCHEMBL1353250 | 0.74 | ADORA2A (0.64) | ADORA2AKDM4ELMNAHPGDMKNK1 | |
| SCHEMBL1355334 | 0.73 | ADORA2A (0.65) | ADORA2AMKNK1MKNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010084425-A1 | NEW ADENOSINE RECEPTOR LIGANDS AND USES THEREOF | DOMAIN THERAPEUTICS (FR) | 2010-07-29 | — | — | WO | disclosed |
| EP-2210891-A1 | New adenosine receptor ligands and uses thereof | Domain Therapeutics (FR) | 2010-07-28 | — | — | EP | disclosed |