SCHEMBL8445

SCHEMBL8445

CCOC(=O)Cc1csc(N)n1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.64
KMT2A Q03164 3/20 0.64
GABRA5 P31644 1/20 0.60
GABRB2 P47870 1/20 0.60
HSD17B10 Q99714 1/20 0.60
ALDH1A1 P00352 3/20 0.59
SMN1; SMN2 Q16637 3/20 0.57
GAA P10253 1/20 0.57
MAPT P10636 2/20 0.56
NPC1 O15118 1/20 0.56
RAB9A P51151 1/20 0.56
LMNA P02545 3/20 0.54
L3MBTL1 Q9Y468 1/20 0.53
MAPK1 P28482 2/20 0.53
TSHR P16473 2/20 0.53
HTT P42858 1/20 0.53
POLB P06746 1/20 0.52
TP53 P04637 1/20 0.52
CYP2C9 P11712 1/20 0.51
CYP2C19 P33261 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8354503 0.88 GABRA5 (0.57) MEN1KMT2AGABRA5GABRB2HSD17B10
Hydrochloric Acid SCHEMBL8356280 0.86 GABRA5 (0.55) MEN1KMT2AGABRA5GABRB2HSD17B10
SCHEMBL8354861 0.85 TSHR (0.58) MEN1KMT2AGABRA5GABRB2HSD17B10
SCHEMBL1081996 0.84 MEN1 (0.54) MEN1KMT2AGABRA5GABRB2HSD17B10
Hydrochloric Acid SCHEMBL8355278 0.84 TSHR (0.57) MEN1KMT2AGABRA5GABRB2HSD17B10
SCHEMBL222254 0.83 HSD17B10 (0.64) MEN1KMT2AGABRA5GABRB2HSD17B10
SCHEMBL1107420 0.83 MEN1 (0.68) MEN1KMT2AALDH1A1SMN1; SMN2GAA
SCHEMBL1525238 0.82 MEN1 (0.66) MEN1KMT2AALDH1A1SMN1; SMN2GAA
SCHEMBL11012092 0.82 MEN1 (0.66) MEN1KMT2AALDH1A1SMN1; SMN2GAA
Hydrochloric Acid SCHEMBL6216313 0.82 HSD17B10 (0.62) MEN1KMT2AGABRA5GABRB2HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 737 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024076331-A1 HYDRAZINECARBOTHIOAMIDE AND 1,2,4-TRIAZOLE-3-THION DERIVATIVE COMPOUNDS CARRYING IMIDAZO[2,1-b]THIAZOLE RING AND SYNTHESIS METHODS OF THESE COMPOUNDS ISTANBUL UNIVERSITESI REKTORLUGU (TR) 2024-04-11 WO claimed
CN-111533710-B Method for preparing cefotiam intermediate 2-aminothiazole-4-acetic acid by one-pot method 江苏恒沛药物科技有限公司 2022-04-22 CN claimed
CN-113461635-A 4- (2-chloroethyl) thiazole-2-carboxylic acid ethyl ester and preparation method and application thereof 上海毕得医药科技股份有限公司 2021-10-01 CN claimed
CN-111533710-A Method for preparing cefotiam intermediate 2-aminothiazole-4-acetic acid by one-pot method 江苏恒沛药物科技有限公司 2020-08-14 CN claimed
CN-101362735-B Preparation method of ethyl 2-[[(bezyloxy)carbonyl]amido]-4-thiazolyl acetate SHANDONG JINCHENG PHARMACEUTICAL & CHEMICALS CO LTD 2011-01-05 CN claimed
WO-2004113310-A1 USE OF AN INHIBITOR OF 11-B-HYDROXYSTEROID DEHYDROGENASE TYPE 1 COMPOUNDS FOR PROMOTING WOUND HEALING BIOVITRUM AB (SE) 2004-12-29 WO claimed
EP-1461327-A1 INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 BIOVITRUM AB (SE) 2004-09-29 EP claimed
WO-2003044000-A1 INHIBITORS OF 11-BETA-HYDROXY STEROID DEHYDROGENASE TYPE 1 BIOVITRUM AB (SE) 2003-05-30 WO claimed
US-6180238-B1 PARTICULARLY SUITABLE FOR USE IN INK JET PRINTING PROCESSES. XEROX CORPORATION 2001-01-30 US claimed
EP-0743574-B1 Migration imaging members XEROX CORP (US) 2000-12-27 EP claimed
US-6106599-A Inks XEROX CORPORATION (US) 2000-08-22 US claimed
EP-0673784-B1 Recording sheets containing oxazole, isooxazole, oxazolidinone, oxazoline salts, morpholine, thiazole, thiazolidine, thiadiazole, and phenothiazine compounds XEROX CORP (US) 1999-10-27 EP claimed
EP-0743573-A2 Method for obtaining image contrast migration imaging members XEROX CORPORATION (US) 1996-11-20 EP claimed
EP-0743574-A2 Migration imaging members XEROX CORPORATION (US) 1996-11-20 EP claimed
US-5563014-A SOFTENABLE LAYER CONTAINIG PHOTOSENSITIVE MARKING MATERIAL; TRANSPARENTIZING AGENT XEROX CORPORATION (US) 1996-10-08 US claimed
US-5514505-A SELECTIVE TRANSPARENTIZATION OF PHOTOSENSITIVE MIGRATION MARKING PARTICLES EMBEDDED NEAR THE SURFACE OF A SOFTENABLE LAYER SUPPORTED BY AN ELECTROCONDUCTIVE SUBSTRATE XEROX CORPORATION (US) 1996-05-07 US claimed
EP-0673784-A2 Recording sheets containing oxazole, isooxazole, oxazolidinone, oxazoline salts, morpholine, thiazole, thiazolidine, thiadiazole, and phenothiazine compounds XEROX CORPORATION (US) 1995-09-27 EP claimed
EP-0527186-A4 UNIV ILLINOIS (US) 1995-01-18 EP claimed
EP-0527186-A1 PHOTODYNAMIC PLANT DEFOLIANTS AND CHLOROPHYLL BIOSYNTHESIS MODULATORS The Board of Trustees for the University of Illinois (US) 1993-02-17 EP claimed
WO-1991016820-A1 PHOTODYNAMIC PLANT DEFOLIANTS AND CHLOROPHYLL BIOSYNTHESIS MODULATORS THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 1991-11-14 WO claimed