Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 9/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 9/20 | 0.38 |
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8442728 | 0.79 | ALK (0.61) | TNIKALK | |
| SCHEMBL16374569 | 0.72 | MAPK8 (0.45) | CDK2 | |
| SCHEMBL3354356 | 0.69 | GCK (0.35) | TNIKALKCLK1DYRK1AMAP3K11 | |
| SCHEMBL3354820 | 0.68 | ALK (0.60) | TNIKALK | |
| SCHEMBL3349746 | 0.67 | CLK1 (0.34) | TNIKALKCLK1DYRK1AMAP3K11 | |
| SCHEMBL3375624 | 0.67 | JAK2 (0.33) | TNIKALKCLK1DYRK1ACLK2 | |
| SCHEMBL18098833 | 0.63 | PDPK1 (0.61) | TNIKKITDYRK1A | |
| SCHEMBL8478199 | 0.63 | AXL (0.47) | TNIKDYRK1ACLK2CLK4CDK2 | |
| SCHEMBL13504976 | 0.61 | AXL (0.42) | TNIKDYRK1ACLK2CLK4CDK2 | |
| SCHEMBL3350898 | 0.61 | MAPK8 (0.52) | TNIKKITDYRK1ACLK2CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749829-A1 | JNK inhibitors | Eisai London Research Laboratories Limited (GB) | 2007-02-07 | — | — | EP | disclosed |