Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.61 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.61 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.61 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.61 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.45 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 11/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.39 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12501063 | 0.83 | PDPK1 (0.69) | PDPK1TGFBR1IKBKETBK1DYRK1A | |
| SCHEMBL12501038 | 0.77 | TGFBR1 (1.00) | PDPK1TGFBR1IKBKETBK1DYRK1A | |
| SCHEMBL18534314 | 0.70 | PDPK1 (0.65) | PDPK1TGFBR1IKBKETBK1TNIK | |
| SCHEMBL12501027 | 0.69 | PDPK1 (0.62) | PDPK1TGFBR1IKBKETNIK | |
| SCHEMBL12501057 | 0.68 | PDPK1 (1.00) | PDPK1TGFBR1IKBKETBK1PIK3CA | |
| SCHEMBL18098840 | 0.68 | PDPK1 (0.66) | PDPK1TGFBR1IKBKETBK1 | |
| SCHEMBL12501148 | 0.66 | PDPK1 (0.61) | PDPK1IKBKETBK1TNIK | |
| SCHEMBL8445064 | 0.63 | TNIK (0.40) | DYRK1AKITTNIK | |
| SCHEMBL16374569 | 0.63 | MAPK8 (0.45) | — | |
| SCHEMBL31380019 | 0.62 | CDK9 (0.67) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2670748-B1 | 7-AZAINDOLE DERIVATIVES | MERCK PATENT GMBH (DE) | 2016-09-28 | — | — | EP | disclosed |