SCHEMBL8445209

SCHEMBL8445209

O=C1CCc2ccccc2N1CCCC1CCN(Cc2ccc(F)cc2F)CC1

nearest known ligand 0.63

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CHRM1 P11229 18/20 0.63
CHRM2 P08172 15/20 0.63
CHRM4 P08173 15/20 0.63
CHRM5 P08912 15/20 0.63
CHRM3 P20309 15/20 0.63
DRD2 P14416 11/20 0.60
DRD4 P21917 11/20 0.60
DRD3 P35462 11/20 0.60
ADRB2 P07550 2/20 0.60
ADRB1 P08588 2/20 0.60
ADRA1D P25100 2/20 0.60
ADRA1A P35348 2/20 0.60
ADRA1B P35368 2/20 0.60
GRIN1 Q05586 2/20 0.51
GRIN2B Q13224 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8443011 0.86 CHRM1 (0.68) CHRM1CHRM2CHRM4CHRM5CHRM3
SCHEMBL8445380 0.82 CHRM2 (0.68) CHRM1CHRM2CHRM4CHRM5CHRM3
SCHEMBL8445224 0.81 CHRM1 (0.74) CHRM1CHRM2CHRM4CHRM5CHRM3
SCHEMBL8442415 0.79 CHRM1 (0.67) CHRM1CHRM2CHRM4CHRM5CHRM3
SCHEMBL8442782 0.79 CHRM2 (0.69) CHRM1CHRM2CHRM4CHRM5CHRM3
SCHEMBL8443141 0.78 CHRM2 (0.68) CHRM1CHRM2CHRM4CHRM5CHRM3
SCHEMBL8442789 0.78 CHRM1 (0.64) CHRM1CHRM2CHRM4CHRM5CHRM3
SCHEMBL8576227 0.78 CHRM1 (0.56) CHRM1CHRM2CHRM4CHRM5CHRM3
SCHEMBL8445194 0.76 CHRM2 (0.64) CHRM1CHRM2CHRM4CHRM5CHRM3
SCHEMBL29400334 0.75 CHRM2 (1.00) CHRM1CHRM2CHRM4CHRM5CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934932-A1 QUINOLINE DERIVATIVES AND PSYCHOTROPIC AGENT MEIJI SEIKA KABUSHIKI KAISHA (JP) 1999-08-11 EP disclosed