Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7940472 | 0.87 | TSHR (0.43) | GBA1TSHRALOX15ALDH1A1LMNA | |
| SCHEMBL9752430 | 0.87 | TSHR (0.43) | GBA1TSHRALOX15ALDH1A1LMNA | |
| SCHEMBL16283436 | 0.86 | GBA1 (0.39) | GBA1TSHRALOX15ALDH1A1HSD17B10 | |
| SCHEMBL3457117 | 0.85 | GBA1 (0.41) | GBA1TSHRALOX15ALDH1A1LMNA | |
| SCHEMBL13016325 | 0.85 | GBA1 (0.41) | GBA1TSHRALOX15ALDH1A1LMNA | |
| SCHEMBL9394550 | 0.83 | GBA1 (0.40) | GBA1TSHRALDH1A1TDP1 | |
| SCHEMBL3429842 | 0.82 | — | — | |
| Ammonia Solution, Strong SCHEMBL10961064 | 0.82 | GBA1 (0.40) | GBA1TSHRALOX15ALDH1A1LMNA | |
| SCHEMBL26003703 | 0.81 | DPP4 (0.34) | GBA1TSHRALOX15ALDH1A1HSD17B10 | |
| SCHEMBL4534651 | 0.80 | ALDH1A1 (0.35) | TSHRALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |