Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 20/20 | 0.48 |
| ▸ | PPARA | Q07869 | 18/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8440670 | 0.81 | PPARG (0.46) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL8445498 | 0.79 | PPARG (0.47) | PPARGPPARAPPARD | |
| SCHEMBL8444677 | 0.78 | PPARG (0.47) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL8440666 | 0.76 | PPARG (0.47) | PPARGPPARAPPARD | |
| SCHEMBL8665426 | 0.73 | PPARG (0.51) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL8500896 | 0.73 | KDM4E (0.46) | PPARGPPARACYP3A4CYP2C9KCNH2 | |
| SCHEMBL13916644 | 0.70 | PPARG (0.62) | PPARGPPARAPPARD | |
| SCHEMBL8691714 | 0.69 | PPARG (0.59) | PPARGPPARAPPARD | |
| SCHEMBL6810525 | 0.69 | PPARG (0.53) | PPARGPPARAPPARD | |
| SCHEMBL8662204 | 0.68 | POLB (0.39) | PPARGPPARACYP3A4CYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5939445-A | ISOXAZOLIDINEDIONES COMPOUNDS AS HYPOGLYCEMIC AGENTS AND TREATMENT OF ARTERIOSCLEROSIS | JAPAN TOBACCO, INC. (JP) | 1999-08-17 | — | — | US | disclosed |
| US-5728720-A | HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; TREATMENT OF DIABETES | JAPAN TOBACCO INC. (JP) | 1998-03-17 | — | — | US | disclosed |