Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.66 |
| ▸ | DRD4 | P21917 | 1/20 | 0.66 |
| ▸ | HTR1A | P08908 | 3/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1318291 | 0.86 | DRD2 (0.62) | DRD2DRD4HTR1AADRA1A | |
| SCHEMBL8446435 | 0.82 | HTR1A (0.53) | DRD2HTR1AADRA1A | |
| SCHEMBL8446436 | 0.82 | HTR1A (0.53) | DRD2HTR1AADRA1A | |
| SCHEMBL8957699 | 0.81 | HTR1D (0.87) | HTR1A | |
| SCHEMBL8446460 | 0.80 | DRD2 (0.85) | DRD2DRD4HTR1AADRA1A | |
| SCHEMBL7703066 | 0.80 | DRD2 (0.85) | DRD2DRD4HTR1AADRA1A | |
| SCHEMBL1315358 | 0.80 | HTR1A (0.59) | DRD4HTR1A | |
| Hydrochloric Acid SCHEMBL9775640 | 0.79 | DRD2 (0.83) | DRD2DRD4HTR1AADRA1A | |
| SCHEMBL6356854 | 0.79 | HTR1D (0.70) | — | |
| SCHEMBL9652838 | 0.78 | DRD2 (0.69) | DRD2DRD4HTR1AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0955296-A2 | Tertiary alkyl functionalized piperazine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-10 | — | — | EP | claimed |
| US-4988814-A | Antidepressants and/or anxiolytic agents | AMERICAN HOME PRODUCTS CORP. (US) | 1991-01-29 | — | — | US | claimed |
| EP-0395313-A2 | Tertiary alkyl functionalized piperazine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-10-31 | — | — | EP | claimed |
| EP-0955296-A2 | Tertiary alkyl functionalized piperazine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-10 | — | — | EP | disclosed |
| US-4988814-A | Antidepressants and/or anxiolytic agents | AMERICAN HOME PRODUCTS CORP. (US) | 1991-01-29 | — | — | US | disclosed |
| EP-0395313-A2 | Tertiary alkyl functionalized piperazine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-10-31 | — | — | EP | disclosed |