Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 8/20 | 0.48 |
| ▸ | F10 | P00742 | 7/20 | 0.48 |
| ▸ | PLAT | P00750 | 7/20 | 0.48 |
| ▸ | F2 | P00734 | 6/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PLG | P00747 | 3/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KLK1 | P06870 | 1/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.37 |
| ▸ | GPR39 | O43194 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8445397 | 0.98 | F10 (0.47) | PLAUF10PLATF2PKM | |
| SCHEMBL8446220 | 0.88 | PLAU (0.48) | PLAUF10PLATF2PLG | |
| SCHEMBL21884580 | 0.86 | PLAU (0.53) | PLAUF10PLATF2HTT | |
| SCHEMBL6671249 | 0.78 | HDAC6 (0.53) | PLAUF10PLATF2PKM | |
| SCHEMBL29803190 | 0.78 | PKM (0.52) | PKMHTTPRKCIAKR1C3AKR1C2 | |
| SCHEMBL322274 | 0.78 | PKM (0.52) | PKMHTTPRKCIAKR1C3AKR1C2 | |
| SCHEMBL23875335 | 0.78 | P2RX1 (0.57) | PKM | |
| SCHEMBL21884653 | 0.78 | PLAU (0.61) | PLAUF10PLATF2HTT | |
| SCHEMBL21884644 | 0.78 | PPIA (0.50) | PLAUF10PLATF2HTT | |
| SCHEMBL21884475 | 0.76 | LMNA (0.42) | PLAUF10PLATF2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0628543-B1 | Substituted benzoylguanidines, process for their preparation, their use as medicament or diagnostic agent, as well as a medicament containing them | HOECHST AG (DE) | 1999-06-16 | — | — | EP | claimed |