SCHEMBL8445983

SCHEMBL8445983

CCSC(F)(F)C1(c2cccc(Cl)c2Cl)CO1

nearest known ligand 0.33

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PDK2 Q15119 3/20 0.33
P2RX7 Q99572 1/20 0.31
CYP2A13 Q16696 2/20 0.31
PDK1 Q15118 1/20 0.30
PDK3 Q15120 1/20 0.30
PDK4 Q16654 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6942412 0.79 SLC6A4 (0.37) PDK2PDK1PDK3PDK4
SCHEMBL6940427 0.68 SLC6A3 (0.37)
SCHEMBL10875357 0.59 GRIN1 (0.44)
SCHEMBL11453212 0.59 CYP2A13 (0.35) P2RX7CYP2A13
SCHEMBL10877467 0.57 TAAR1 (0.41)
Fluoromethane SCHEMBL28306611 0.56 TSHR (0.52)
SCHEMBL25156642 0.56 KDM1A (0.41) PDK2
SCHEMBL30344161 0.56 KDM1A (0.41) PDK2
SCHEMBL8207739 0.56 TSHR (0.38) PDK2
SCHEMBL3613800 0.55 TAAR1 (0.78)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0927719-A1 Triazole derivative or salt thereof, preparation process thereof as well as pharmaceutical containing said compound SSP Co., Ltd. (JP) 1999-07-07 EP disclosed