Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.40 |
| ▸ | NNMT | P40261 | 3/20 | 0.40 |
| ▸ | PI4KA | P42356 | 3/20 | 0.39 |
| ▸ | PI4K2B | Q8TCG2 | 3/20 | 0.39 |
| ▸ | PI4K2A | Q9BTU6 | 3/20 | 0.39 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.38 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.38 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.38 |
| ▸ | GAPDH | P04406 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30515021 | 0.85 | EGFR (0.53) | EGFRERBB2ADORA2API4KAPI4K2B | |
| SCHEMBL160359 | 0.85 | EGFR (0.53) | EGFRERBB2ADORA2API4KAPI4K2B | |
| Niacinamide SCHEMBL8447045 | 0.84 | EGFR (0.47) | EGFRSRCKDRADORA2ANNMT | |
| Phosphoric Acid SCHEMBL28300969 | 0.83 | EGFR (0.48) | EGFRERBB2ADORA2API4KAPI4K2B | |
| Pyrimidine SCHEMBL27654880 | 0.79 | PI4KA (0.50) | EGFRERBB2ADORA2API4KAPI4K2B | |
| SCHEMBL8859843 | 0.78 | EGFR (0.48) | EGFRSRCKDRADORA2API4KA | |
| Niacinamide SCHEMBL28275359 | 0.77 | EGFR (0.53) | EGFRSRCKDRADORA2ANNMT | |
| SCHEMBL16258664 | 0.76 | PI4KA (0.55) | EGFRERBB2ADORA2API4KAPI4K2B | |
| SCHEMBL41360 | 0.76 | PI4KA (0.55) | EGFRERBB2ADORA2API4KAPI4K2B | |
| SCHEMBL3794703 | 0.76 | PI4KA (0.55) | EGFRERBB2ADORA2API4KAPI4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824345-A4 | S-ADENOSYL METHIONINE REGULATION OF METABOLIC PATHWAYS AND ITS USE IN DIAGNOSIS AND THERAPY | ORIDIGM CORP (US) | 1999-08-25 | — | — | EP | disclosed |
| EP-0824345-A1 | S-ADENOSYL METHIONINE REGULATION OF METABOLIC PATHWAYS AND ITS USE IN DIAGNOSIS AND THERAPY | ORIDIGM CORPORATION (US) | 1998-02-25 | — | — | EP | disclosed |
| WO-1996033703-A2 | S-ADENOSYL METHIONINE REGULATION OF METABOLIC PATHWAYS AND ITS USE IN DIAGNOSIS AND THERAPY | ORIDIGM CORPORATION (US) | 1996-10-31 | — | — | WO | disclosed |