Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MAP2 | P11137 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16599058 | 0.89 | ALDH1A1 (0.49) | KDM4EALDH1A1HPGDMAP2MEN1 | |
| SCHEMBL1613575 | 0.84 | KDM4E (0.61) | KDM4EALDH1A1HPGDMAP2MEN1 | |
| SCHEMBL30220650 | 0.84 | KDM4E (0.61) | KDM4EALDH1A1HPGDMAP2MEN1 | |
| SCHEMBL28911042 | 0.82 | KDM4E (0.51) | KDM4EALDH1A1HPGDMAP2MEN1 | |
| SCHEMBL9654119 | 0.79 | KDM4E (0.57) | KDM4EALDH1A1HPGDMAP2MEN1 | |
| SCHEMBL8343752 | 0.79 | ALDH1A1 (0.56) | KDM4EALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL27949659 | 0.79 | MAP2 (0.49) | KDM4EALDH1A1HPGDMAP2MEN1 | |
| SCHEMBL29150402 | 0.79 | MAP2 (0.51) | KDM4EALDH1A1HPGDMAP2MEN1 | |
| SCHEMBL30601629 | 0.79 | MAP2 (0.60) | KDM4EALDH1A1HPGDMAP2MEN1 | |
| SCHEMBL2730936 | 0.79 | MAP2 (0.60) | KDM4EALDH1A1HPGDMAP2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1124262-C | Indole derivatives as endothelin receptor antagonists | PFIZER (US) | 2003-10-15 | — | — | CN | disclosed |
| CN-1216531-A | Indole derivatives as endothelin receptor antagonists | PFIZER (US) | 1999-05-12 | — | — | CN | disclosed |
| WO-1999020623-A1 | INDOLE DERIVATIVE USEFUL AS ENDOTHELIN RECEPTOR ANTAGONIST | PFIZER LIMITED (GB) | 1999-04-29 | — | — | WO | disclosed |
| EP-0901470-A1 | INDOLE DERIVATIVES USEFUL AS ENDOTHELIN RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997043260-A1 | INDOLE DERIVATIVES USEFUL AS ENDOTHELIN RECEPTOR ANTAGONISTS | PFIZER INC. (US) | 1997-11-20 | — | — | WO | disclosed |