Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 9/20 | 0.40 |
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | POLA1 | P09884 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | PAK4 | O96013 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26650728 | 0.79 | ALDH1A1 (0.41) | GAAMAPTALDH1A1KMT2APKM | |
| SCHEMBL31373525 | 0.79 | ALDH1A1 (0.41) | GAAMAPTALDH1A1KMT2APKM | |
| SCHEMBL7171477 | 0.77 | CYP2D6 (0.56) | GAAMAPTALDH1A1KMT2AKDM4E | |
| SCHEMBL2721693 | 0.76 | KMT2A (0.46) | GAAMAPTALDH1A1KMT2APKM | |
| SCHEMBL23321305 | 0.75 | MAPT (0.48) | GAAMAPTKMT2AKDM4EAGTR1 | |
| SCHEMBL18103976 | 0.74 | ALDH1A1 (0.42) | GAAMAPTALDH1A1KMT2APKM | |
| SCHEMBL12322288 | 0.74 | DAPK3 (0.61) | GAAMAPTALDH1A1KDM4ELMNA | |
| SCHEMBL27673819 | 0.73 | MAPT (0.40) | GAAMAPTALDH1A1KMT2APKM | |
| SCHEMBL18689678 | 0.71 | ALDH1A1 (0.43) | GAAMAPTALDH1A1KMT2APKM | |
| SCHEMBL4648295 | 0.71 | MAPT (0.41) | GAAMAPTALDH1A1KMT2APKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999000669-A1 | NUCLEOBASE HETEROCYCLIC COMBINATORIALIZATION | ISIS PHARMACEUTICALS, INC. (US) | 1999-01-07 | — | — | WO | disclosed |