Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.78 |
| ▸ | HPGD | P15428 | 5/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.78 |
| ▸ | CA1 | P00915 | 2/20 | 0.78 |
| ▸ | CA9 | Q16790 | 2/20 | 0.78 |
| ▸ | CA12 | O43570 | 1/20 | 0.78 |
| ▸ | CA2 | P00918 | 1/20 | 0.78 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.78 |
| ▸ | CA4 | P22748 | 1/20 | 0.78 |
| ▸ | CA6 | P23280 | 1/20 | 0.78 |
| ▸ | CA7 | P43166 | 1/20 | 0.78 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.78 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.78 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | MPO | P05164 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL29362663 | 0.89 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDSMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL17156443 | 0.89 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDSMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL29606432 | 0.89 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDSMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL8433746 | 0.89 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDSMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL1509155 | 0.89 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDSMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL29360246 | 0.89 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDSMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL1967 | 0.89 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDSMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL3677988 | 0.87 | ALDH1A1 (0.78) | ALDH1A1KDM4EHPGDSMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL3788498 | 0.86 | ALDH1A1 (0.95) | ALDH1A1KDM4EHPGDSMN1; SMN2CA1 | |
| Salicylic Acid SCHEMBL9691144 | 0.86 | ALDH1A1 (0.95) | ALDH1A1KDM4EHPGDSMN1; SMN2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9011734-B2 | Ligand exchange thermochromic, (LETC), systems | PLEOTINT, L.L.C. (US) | 2015-04-21 | — | — | US | claimed |
| US-8018639-B2 | Ligand exchange thermochromic, (LETC), systems | PLEOTINT, L.L.C. (US) | 2011-09-13 | — | — | US | claimed |
| US-20090283728-A1 | LIGAND EXCHANGE THERMOCHROMIC, (LETC), SYSTEMS | PLEOTINT, LLC (US) | 2009-11-19 | — | — | US | claimed |
| EP-2082005-A1 | LIGAND EXCHANGE THERMOCHROMIC, (LETC), SYSTEMS | Pleotint, L.L.C. (US) | 2009-07-29 | — | — | EP | claimed |
| US-20080100902-A1 | LIGAND EXCHANGE THERMOCHROMIC, (LETC), SYSTEMS | PLEOTINT, LLC (US) | 2008-05-01 | — | — | US | claimed |
| WO-2008028128-A1 | LIGAND EXCHANGE THERMOCHROMIC, (LETC), SYSTEMS | PLEOTINT, L.L.C. (US) | 2008-03-06 | — | — | WO | claimed |
| EP-2436750-A2 | Ligand exchange thermochromic, (LETC), systems | Pleotint, L.L.C. (US) | 2012-04-04 | — | — | EP | disclosed |
| EP-2434000-A2 | Ligand exchange thermochromic, (LETC), systems | Pleotint, L.L.C. (US) | 2012-03-28 | — | — | EP | disclosed |
| US-7253232-B2 | Thermoplastic compositions with enhanced melt flow and compatibility | CIBA SPECIALTY CHEMICALS CORP. (US) | 2007-08-07 | — | — | US | disclosed |
| US-20070064195-A1 | Stabilization of photochromic systems | CIBA CORPORATION | 2007-03-22 | — | — | US | disclosed |
| US-20050288435-A1 | Thermoplastic compositions with enhanced melt flow and compatibility | CIBA SPECIALTY CHEMICALS CORP. | 2005-12-29 | — | — | US | disclosed |
| US-5449776-A | Polypropylene | CIBA-GEIGY CORPORATION (US) | 1995-09-12 | — | — | US | disclosed |