Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CRHBP | P24387 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20108 | 0.73 | ALOX15 (0.43) | ALOX15MAPK1TP53HSD17B10SMN1; SMN2 | |
| SCHEMBL1490037 | 0.73 | HPGD (0.47) | ALOX15MAPK1TP53HSD17B10SMN1; SMN2 | |
| SCHEMBL30442982 | 0.73 | ALOX15 (0.43) | ALOX15MAPK1TP53HSD17B10SMN1; SMN2 | |
| SCHEMBL18758433 | 0.71 | ALOX15 (0.42) | ALOX15MAPK1TP53HSD17B10SMN1; SMN2 | |
| SCHEMBL22861454 | 0.71 | ALOX15 (0.42) | ALOX15MAPK1TP53HSD17B10SMN1; SMN2 | |
| SCHEMBL1529233 | 0.71 | ALOX15 (0.42) | ALOX15MAPK1TP53HSD17B10SMN1; SMN2 | |
| SCHEMBL21614018 | 0.71 | ALOX15 (0.42) | ALOX15MAPK1TP53HSD17B10SMN1; SMN2 | |
| SCHEMBL1770329 | 0.71 | SMN1; SMN2 (0.46) | ALOX15MAPK1TP53HSD17B10SMN1; SMN2 | |
| SCHEMBL1531092 | 0.71 | ALOX15 (0.55) | ALOX15MAPK1TP53HSD17B10SMN1; SMN2 | |
| Lithium SCHEMBL31258223 | 0.71 | ALOX15 (0.42) | ALOX15MAPK1TP53HSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116134018-A | 2-oxoimidazolidine-4-carboxamide as NAV1.8 inhibitor | 默沙东有限责任公司 | 2023-05-16 | — | — | CN | disclosed |
| CN-116056697-A | 2-oxo-oxazolidine-5-carboxamides as NAV1.8 inhibitors | 默沙东有限责任公司 | 2023-05-02 | — | — | CN | disclosed |
| EP-0942909-A1 | BICYCLIC AMINE DERIVATIVES | ZENECA LIMITED (GB) | 1999-09-22 | — | — | EP | disclosed |
| US-5849754-A | Bicyclic amine derivatives | ZENECA LIMITED (GB) | 1998-12-15 | — | — | US | disclosed |
| WO-1998022463-A1 | BICYCLIC AMINE DERIVATIVES | ZENECA LIMITED (GB) | 1998-05-28 | — | — | WO | disclosed |