Nitrofurazone

Nitrofurazone

SCHEMBL8448657

CC(C)[C@H](N)C(=O)O.NC(=O)N/N=C/c1ccc([N+](=O)[O-])o1

nearest known ligand 0.76

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 7/20 0.76
ALDH1A1 P00352 5/20 0.76
CYP3A4 P08684 3/20 0.76
CYP1A2 P05177 3/20 0.76
KDM4E B2RXH2 2/20 0.76
SMN1; SMN2 Q16637 2/20 0.76
TP53 P04637 2/20 0.76
CYP2D6 P10635 1/20 0.76
HIF1A Q16665 1/20 0.76
PDE3A Q14432 1/20 0.76
SARM1 Q6SZW1 1/20 0.76
HTT P42858 5/20 0.61
TDP1 Q9NUW8 3/20 0.61
POLB P06746 5/20 0.59
CYP2C19 P33261 1/20 0.55
L3MBTL1 Q9Y468 2/20 0.54
CASP6 P55212 1/20 0.54
MAPT P10636 9/20 0.53
MITF O75030 3/20 0.53
RAB9A P51151 2/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nitrofurazone SCHEMBL25417 0.87 LMNA (1.00) LMNAALDH1A1CYP3A4CYP1A2KDM4E
Nitrofurazone SCHEMBL3681048 0.87 LMNA (1.00) LMNAALDH1A1CYP3A4CYP1A2KDM4E
Nitrofurazone SCHEMBL25416 0.87 LMNA (1.00) LMNAALDH1A1CYP3A4CYP1A2KDM4E
Nitrofurazone SCHEMBL28198181 0.86 LMNA (0.97) LMNAALDH1A1CYP3A4CYP1A2KDM4E
Nitrofurazone SCHEMBL28285714 0.84 LMNA (0.94) LMNAALDH1A1CYP3A4CYP1A2KDM4E
Nitrofurazone SCHEMBL9928793 0.83 LMNA (0.87) LMNAALDH1A1CYP3A4CYP1A2KDM4E
Nitrofurazone SCHEMBL20775188 0.83 LMNA (0.87) LMNAALDH1A1CYP3A4CYP1A2KDM4E
Nitrofurazone SCHEMBL9054779 0.81 LMNA (0.83) LMNAALDH1A1CYP3A4CYP1A2KDM4E
Nitrofurazone SCHEMBL28246849 0.81 LMNA (0.83) LMNAALDH1A1CYP3A4CYP1A2KDM4E
Nitrofurazone SCHEMBL28871281 0.81 LMNA (0.81) LMNAALDH1A1CYP3A4CYP1A2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0896541-A4 1999-03-24 EP disclosed
EP-0896541-A1 SILVER-BASED PHARMACEUTICAL COMPOSITIONS CAPELLI, Christopher C. (US) 1999-02-17 EP disclosed
WO-1997002038-A1 SILVER-BASED PHARMACEUTICAL COMPOSITIONS CAPELLI CHRISTOPHER C (US) 1997-01-23 WO disclosed