Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.39 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13272192 | 0.90 | MAPK1 (0.52) | MAPK1L3MBTL1ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL845235 | 0.90 | MAPK1 (0.52) | MAPK1L3MBTL1ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL845304 | 0.90 | MAPK1 (0.52) | MAPK1L3MBTL1ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL13272186 | 0.88 | MAPK1 (0.51) | MAPK1L3MBTL1ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL845288 | 0.88 | MAPK1 (0.51) | MAPK1L3MBTL1ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL844902 | 0.88 | ALDH1A1 (0.47) | MAPK1ALDH1A1HTTCYP2C9CYP2C19 | |
| SCHEMBL844977 | 0.88 | MAPK1 (0.50) | MAPK1L3MBTL1ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL845486 | 0.88 | MAPK1 (0.50) | MAPK1L3MBTL1ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL13272388 | 0.80 | VHL (0.43) | ALDH1A1NPSR1CYP2C9CYP2C19MEN1 | |
| SCHEMBL845253 | 0.80 | VHL (0.43) | ALDH1A1NPSR1CYP2C9CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| EP-1893573-B1 | INHIBITORS OF HCV REPLICATION | BRISTOL MYERS SQUIBB CO (US) | 2010-07-21 | — | — | EP | disclosed |