Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM3 | Q86V86 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | CDK4 | P11802 | 3/20 | 0.46 |
| ▸ | CCND1 | P24385 | 3/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | ACLY | P53396 | 1/20 | 0.38 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL844942 | 1.00 | PIM3 (0.64) | PIM3NPC1CDK4CCND1CCNE2 | |
| SCHEMBL844580 | 0.87 | PIM3 (0.62) | PIM3NPC1CDK4CCND1CCNE2 | |
| SCHEMBL12234734 | 0.87 | PIM3 (0.62) | PIM3NPC1CDK4CCND1CCNE2 | |
| SCHEMBL12324523 | 0.85 | JAK2 (0.50) | PIM3NPC1CDK4CCND1KIF11 | |
| SCHEMBL844301 | 0.84 | PIM3 (0.53) | PIM3CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL844541 | 0.83 | PIM3 (0.58) | PIM3NPC1KIF11CHUK | |
| SCHEMBL844676 | 0.81 | PIM3 (0.56) | PIM3CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL844551 | 0.80 | KIF11 (0.61) | PIM3CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL844827 | 0.80 | PIM3 (0.54) | PIM3CDK4CCND1CCNE2CCNE1 | |
| SCHEMBL844356 | 0.78 | PIM3 (0.68) | PIM3CDK4CCND1CCNE2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481586-B2 | Pyrrolo[2,3-a] carbazoles and use thereof as PIM kinase inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-07-09 | — | — | US | claimed |
| EP-2326649-B1 | NOVEL PYRROLO[2,3-a]CARBAZOLES AND USE THEREOF AS PIM KINASE INHIBITORS | CENTRE NAT RECH SCIENT (FR) | 2012-03-28 | — | — | EP | claimed |
| US-20110263669-A1 | Novel Pyrrolo [2,3-A] Carbazoles and Use Thereof as PIM Kinase Inhibitors | UNIVERSITE BLAISE PASCAL-CLERMONT-FERRAND II (FR) | 2011-10-27 | — | — | US | claimed |
| JP-2011526610-A | — | — | 2011-10-13 | — | — | JP | claimed |
| EP-2326649-A1 | NOVEL PYRROLO Ý2,3-A¨CARBAZOLES AND USE THEREOF AS PIM KINASE INHIBITORS | Centre National de la Recherche Scientifique (FR) | 2011-06-01 | — | — | EP | claimed |
| WO-2010000978-A1 | NOVEL PYRROLO [2,3-A] CARBAZOLES AND USE THEREOF AS PIM KINASE INHIBITORS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2010-01-07 | — | — | WO | claimed |
| US-8481586-B2 | Pyrrolo[2,3-a] carbazoles and use thereof as PIM kinase inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-07-09 | — | — | US | disclosed |
| US-8481586-B2 | Pyrrolo[2,3-a] carbazoles and use thereof as PIM kinase inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-07-09 | — | — | US | disclosed |
| US-8481586-B2 | Pyrrolo[2,3-a] carbazoles and use thereof as PIM kinase inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-07-09 | — | — | US | disclosed |
| EP-2326649-B1 | NOVEL PYRROLO[2,3-a]CARBAZOLES AND USE THEREOF AS PIM KINASE INHIBITORS | CENTRE NAT RECH SCIENT (FR) | 2012-03-28 | — | — | EP | disclosed |
| US-20110263669-A1 | Novel Pyrrolo [2,3-A] Carbazoles and Use Thereof as PIM Kinase Inhibitors | UNIVERSITE BLAISE PASCAL-CLERMONT-FERRAND II (FR) | 2011-10-27 | — | — | US | disclosed |
| US-20110263669-A1 | Novel Pyrrolo [2,3-A] Carbazoles and Use Thereof as PIM Kinase Inhibitors | UNIVERSITE BLAISE PASCAL-CLERMONT-FERRAND II (FR) | 2011-10-27 | — | — | US | disclosed |
| US-20110263669-A1 | Novel Pyrrolo [2,3-A] Carbazoles and Use Thereof as PIM Kinase Inhibitors | UNIVERSITE BLAISE PASCAL-CLERMONT-FERRAND II (FR) | 2011-10-27 | — | — | US | disclosed |
| WO-2010000978-A1 | NOVEL PYRROLO [2,3-A] CARBAZOLES AND USE THEREOF AS PIM KINASE INHIBITORS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263669-A1 | Novel Pyrrolo [2,3-A] Carbazoles and Use Thereof as PIM Kinase Inhibitors | PIM3, PIM1, PIM2 | PIM3 1/4885NPC1 3295/4885CDK4 187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.