Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 5/20 | 0.61 |
| ▸ | PIM3 | Q86V86 | 5/20 | 0.61 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.56 |
| ▸ | CDK4 | P11802 | 1/20 | 0.56 |
| ▸ | CCND1 | P24385 | 1/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.56 |
| ▸ | CDK2 | P24941 | 1/20 | 0.56 |
| ▸ | GABRP | O00591 | 2/20 | 0.50 |
| ▸ | GABRD | O14764 | 2/20 | 0.50 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.50 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.50 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.50 |
| ▸ | GABRE | P78334 | 2/20 | 0.50 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20836852 | 0.93 | KIF11 (0.67) | KIF11PIM3CCNE2CDK4CCND1 | |
| SCHEMBL20836855 | 0.88 | CDK4 (0.63) | KIF11PIM3CCNE2CDK4CCND1 | |
| SCHEMBL29378455 | 0.82 | KIF11 (0.71) | KIF11PIM3GABRPGABRDGABRA1 | |
| SCHEMBL191347 | 0.82 | KIF11 (0.71) | KIF11PIM3GABRPGABRDGABRA1 | |
| SCHEMBL844942 | 0.80 | PIM3 (0.64) | KIF11PIM3CCNE2CDK4CCND1 | |
| SCHEMBL844971 | 0.80 | PIM3 (0.64) | KIF11PIM3CCNE2CDK4CCND1 | |
| Indole SCHEMBL28012893 | 0.80 | KIF11 (0.69) | KIF11PIM3CCNE2CDK4CCND1 | |
| SCHEMBL20836242 | 0.80 | GABRP (0.57) | KIF11PIM3CCNE2CDK4CCND1 | |
| SCHEMBL20836850 | 0.78 | KIF11 (0.57) | KIF11PIM3CCNE2CDK4CCND1 | |
| SCHEMBL20836856 | 0.78 | KIF11 (0.57) | KIF11PIM3CCNE2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481586-B2 | Pyrrolo[2,3-a] carbazoles and use thereof as PIM kinase inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-07-09 | — | — | US | claimed |
| EP-2326649-B1 | NOVEL PYRROLO[2,3-a]CARBAZOLES AND USE THEREOF AS PIM KINASE INHIBITORS | CENTRE NAT RECH SCIENT (FR) | 2012-03-28 | — | — | EP | claimed |
| US-20110263669-A1 | Novel Pyrrolo [2,3-A] Carbazoles and Use Thereof as PIM Kinase Inhibitors | UNIVERSITE BLAISE PASCAL-CLERMONT-FERRAND II (FR) | 2011-10-27 | — | — | US | claimed |
| US-9356243-B2 | Materials for organic electroluminescent devices | MERCK PATENT GMBH (DE) | 2016-05-31 | — | — | US | disclosed |
| US-9356243-B2 | Materials for organic electroluminescent devices | MERCK PATENT GMBH (DE) | 2016-05-31 | — | — | US | disclosed |
| US-20140350243-A1 | MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES | MERCH PATENT GMBH (DE) | 2014-11-27 | — | — | US | disclosed |
| US-20140350243-A1 | MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES | MERCH PATENT GMBH (DE) | 2014-11-27 | — | — | US | disclosed |
| US-8835626-B2 | Materials for organic electroluminescent devices | MERCK PATENT GMBH (DE) | 2014-09-16 | — | — | US | disclosed |
| US-8835626-B2 | Materials for organic electroluminescent devices | MERCK PATENT GMBH (DE) | 2014-09-16 | — | — | US | disclosed |
| US-8481586-B2 | Pyrrolo[2,3-a] carbazoles and use thereof as PIM kinase inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-07-09 | — | — | US | disclosed |
| US-8481586-B2 | Pyrrolo[2,3-a] carbazoles and use thereof as PIM kinase inhibitors | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-07-09 | — | — | US | disclosed |
| US-20030207863-A1 | Preventives and remedies for central nervous system diseases | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2003-11-06 | — | — | US | disclosed |
| EP-1331010-A1 | PREVENTIVES AND REMEDIES FOR CENTRAL NERVOUS SYSTEM DISEASES | Takeda Chemical Industries, Ltd. (JP) | 2003-07-30 | — | — | EP | disclosed |
| EP-1310490-A1 | GPR14 ANTAGONIST | Takeda Chemical Industries, Ltd. (JP) | 2003-05-14 | — | — | EP | disclosed |
| EP-1308513-A1 | USE OF POLYPEPTIDE | Takeda Chemical Industries, Ltd. (JP) | 2003-05-07 | — | — | EP | disclosed |
| US-6534496-B1 | Prophylactic and/or therapeutic drug for obesity and obesity associated diseasestor diabetes with a reduced risk for central side effects and high universality in usage. Another object of the a lipolytic agent, or a prophylactic and/or | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2003-03-18 | — | — | US | disclosed |
| US-20020177593-A1 | Agents and crystals for improving excretory potency of urinary bladder | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2002-11-28 | — | — | US | disclosed |
| EP-1118322-A1 | DRUGS FOR IMPROVING VESICAL EXCRETORY STRENGTH | Takeda Chemical Industries, Ltd. (JP) | 2001-07-25 | — | — | EP | disclosed |
| US-5620973-A | CHOLINESTERASE INHIBITOR; ALZHEIMER*S DISEASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-04-15 | — | — | US | disclosed |
| EP-0655451-A1 | Tetracyclic condensed heterocyclic compounds for the treatment of senile dementia | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-05-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020177593-A1 | Agents and crystals for improving excretory potency of urinary bladder | ACHE, BPHL, BCHE | KIF11 1769/4885PIM3 4215/4885CCNE2 1356/4885 |
| US-20110263669-A1 | Novel Pyrrolo [2,3-A] Carbazoles and Use Thereof as PIM Kinase Inhibitors | PIM3, PIM1, PIM2 | KIF11 1961/4885PIM3 1/4885CCNE2 3339/4885 |
| US-20030207863-A1 | Preventives and remedies for central nervous system diseases | UTS2R, PRSS12, CTSA | KIF11 4778/4885PIM3 4842/4885CCNE2 4078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.