Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 13/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.62 |
| ▸ | PDE2A | O00408 | 2/20 | 0.59 |
| ▸ | PDE9A | O76083 | 2/20 | 0.59 |
| ▸ | PDE4A | P27815 | 2/20 | 0.59 |
| ▸ | PDE6C | P51160 | 2/20 | 0.59 |
| ▸ | PDE1A | P54750 | 2/20 | 0.59 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.59 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.59 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29655374 | 0.88 | KMT2A (0.83) | PDE5AKMT2AALDH1A1KDM4EPDE2A | |
| SCHEMBL1071 | 0.88 | KMT2A (0.83) | PDE5AKMT2AALDH1A1KDM4EPDE2A | |
| SCHEMBL12047452 | 0.83 | CA12 (0.60) | PDE5A | |
| SCHEMBL7543611 | 0.82 | PDE5A (0.54) | PDE5AKMT2AKDM4E | |
| SCHEMBL6642885 | 0.82 | KMT2A (0.59) | PDE5AKMT2ANPSR1ALDH1A1KDM4E | |
| SCHEMBL6644911 | 0.82 | KMT2A (0.59) | PDE5AKMT2ANPSR1ALDH1A1KDM4E | |
| SCHEMBL973746 | 0.82 | PDE5A (0.68) | PDE5AKMT2AKDM4EPDE2APDE9A | |
| SCHEMBL31202676 | 0.81 | KMT2A (0.73) | PDE5AKMT2AKDM4EPDE2APDE9A | |
| SCHEMBL1253 | 0.81 | KMT2A (0.73) | PDE5AKMT2AKDM4EPDE2APDE9A | |
| SCHEMBL1392 | 0.81 | PDE5A (1.00) | PDE5AKMT2AALDH1A1KDM4EPDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6200980-B1 | ADMINISTERING PHENYL PURINONE COMPOUND FOR TREATING PRECANCEROUS LEISONS | CELL PATHWAYS, INC. | 2001-03-13 | — | — | US | disclosed |
| EP-0463756-B1 | Pyrazolopyrimidinone antianginal agents | PFIZER LTD (GB) | 1995-04-19 | — | — | EP | disclosed |
| US-5346901-A | Treatment of angina, hypertension, heart failure and atherosclerosis | PFIZER INC. (US) | 1994-09-13 | — | — | US | disclosed |
| US-5250534-A | Inhibitors of cyclic guanosine 3*,5*-monophosphate phosphodiesterase | PFIZER INC. (US) | 1993-10-05 | — | — | US | disclosed |
| WO-1993006104-A1 | PYRAZOLOPYRIMIDINONE ANTIANGINAL AGENTS | PFIZER LIMITED (GB) | 1993-04-01 | — | — | WO | disclosed |
| EP-0463756-A1 | Pyrazolopyrimidinone antianginal agents | Pfizer Limited (GB) | 1992-01-02 | — | — | EP | disclosed |