Fluocinolone Acetonide

SCHEMBL8450831

CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1.CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1

nearest known ligand 0.77

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Fluocinolone Acetonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	NR3C1 known ✓	P04150	9/20	0.77

▸	LMNA	P02545	7/20	0.77

▸	PGR	P06401	6/20	0.77

▸	CYP3A4	P08684	5/20	0.77

▸	HIF1A	Q16665	5/20	0.77

▸	HSD17B10	Q99714	3/20	0.77

▸	AR	P10275	3/20	0.77

▸	KDM4E	B2RXH2	2/20	0.77

▸	MAPT	P10636	1/20	0.77

▸	TDP1	Q9NUW8	1/20	0.77

▸	MAPK1	P28482	1/20	0.77

▸	ABCB11	O95342	2/20	0.68

▸	CYP2C19	P33261	1/20	0.68

▸	NR1I2	O75469	1/20	0.68

▸	HTR1A	P08908	1/20	0.68

▸	ADRA2A	P08913	1/20	0.68

▸	ADRA1A	P35348	1/20	0.68

▸	ALDH1A1	P00352	1/20	0.64

▸	MEN1	O00255	1/20	0.64

▸	KMT2A	Q03164	1/20	0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Fluocinonide SCHEMBL616754	0.95	NR3C1 (0.74)	NR3C1LMNAPGRCYP3A4HIF1A
Fluocinolone Acetonide SCHEMBL2251974	0.91	NR3C1 (0.82)	NR3C1LMNAPGRCYP3A4HIF1A
Triamcinolone Acetonide SCHEMBL20915153	0.90	HIF1A (0.77)	NR3C1LMNAPGRCYP3A4HIF1A
Betamethasone Valerate SCHEMBL8449742	0.88	NR3C1 (0.64)	NR3C1LMNAPGRCYP3A4HIF1A
Fluocinolone Acetonide SCHEMBL4116560	0.88	NR3C1 (1.00)	NR3C1LMNAPGRCYP3A4HIF1A
Fluocinolone Acetonide SCHEMBL13799272	0.88	NR3C1 (1.00)	NR3C1LMNAPGRCYP3A4HIF1A
Fluocinolone Acetonide SCHEMBL21153661	0.88	NR3C1 (1.00)	NR3C1LMNAPGRCYP3A4HIF1A
Fluocinolone Acetonide SCHEMBL12323210	0.88	NR3C1 (1.00)	NR3C1LMNAPGRCYP3A4HIF1A
Fluocinolone Acetonide SCHEMBL13695922	0.88	NR3C1 (1.00)	NR3C1LMNAPGRCYP3A4HIF1A
Fluocinolone Acetonide SCHEMBL11911287	0.88	NR3C1 (1.00)	NR3C1LMNAPGRCYP3A4HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-0896541-A4	—	—	1999-03-24	—	—	EP	disclosed
EP-0896541-A1	SILVER-BASED PHARMACEUTICAL COMPOSITIONS	CAPELLI, Christopher C. (US)	1999-02-17	—	—	EP	disclosed
WO-1997002038-A1	SILVER-BASED PHARMACEUTICAL COMPOSITIONS	CAPELLI CHRISTOPHER C (US)	1997-01-23	—	—	WO	disclosed