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Triamcinolone Acetonide

Triamcinolone Acetonide

SCHEMBL20915153

CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1.CC1(C)O[C@@H]2C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@]2(C(=O)CO)O1

nearest known ligand 0.77

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Triamcinolone Acetonide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 7/20 0.77
▸ HIF1A Q16665 8/20 0.77
▸ LMNA P02545 7/20 0.77
▸ CYP3A4 P08684 7/20 0.77
▸ PGR P06401 7/20 0.77
▸ KDM4E B2RXH2 2/20 0.77
▸ HSD17B10 Q99714 2/20 0.77
▸ ABCB11 O95342 2/20 0.77
▸ CYP2C19 P33261 1/20 0.77
▸ NR1I2 O75469 1/20 0.77
▸ HTR1A P08908 1/20 0.77
▸ ADRA2A P08913 1/20 0.77
▸ ADRA1A P35348 1/20 0.77
▸ AR P10275 3/20 0.68
▸ MAPT P10636 2/20 0.68
▸ TDP1 Q9NUW8 1/20 0.68
▸ MAPK1 P28482 1/20 0.68
▸ NPSR1 Q6W5P4 3/20 0.62
▸ SMN1; SMN2 Q16637 1/20 0.57
▸ ALDH1A1 P00352 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Flunisolide SCHEMBL20915050 0.95 CYP3A4 (0.69) HIF1ALMNACYP3A4NR3C1PGR
Fluocinolone Acetonide SCHEMBL2251974 0.91 NR3C1 (0.82) HIF1ALMNACYP3A4NR3C1PGR
Fluocinolone Acetonide SCHEMBL8450831 0.90 NR3C1 (0.77) HIF1ALMNACYP3A4NR3C1PGR
Flunisolide SCHEMBL9987242 0.90 CYP3A4 (0.61) HIF1ALMNACYP3A4NR3C1PGR
Triamcinolone Acetonide SCHEMBL5457484 0.88 CYP3A4 (0.69) HIF1ALMNACYP3A4NR3C1PGR
Flunisolide SCHEMBL5187487 0.88 CYP3A4 (1.00) HIF1ALMNACYP3A4NR3C1PGR
Flunisolide SCHEMBL5493687 0.88 CYP3A4 (1.00) HIF1ALMNACYP3A4NR3C1PGR
Flunisolide SCHEMBL4351 0.88 CYP3A4 (1.00) HIF1ALMNACYP3A4NR3C1PGR
Flunisolide SCHEMBL8810954 0.88 CYP3A4 (1.00) HIF1ALMNACYP3A4NR3C1PGR
Flunisolide SCHEMBL13026142 0.88 CYP3A4 (1.00) HIF1ALMNACYP3A4NR3C1PGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10544147-B2 Purine inhibitors of human phosphatidylinositol 3-kinase delta MERCK SHARP & DOHME CORP. (US) 2020-01-28 — — US disclosed
US-20190119278-A1 Purine Inhibitors of Human Phosphatidylinositol 3-Kinase Delta MERCK SHARP & DOHME CORP. (US) 2019-04-25 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190119278-A1 Purine Inhibitors of Human Phosphatidylinositol 3-Kinase Delta PIK3CD, PIK3CA, PI4KA NR3C1 2552/4885HIF1A 901/4885LMNA 3136/4885
US-10544147-B2 Purine inhibitors of human phosphatidylinositol 3-kinase delta PIK3CD, PIK3CA, PI4KA NR3C1 2552/4885HIF1A 901/4885LMNA 3136/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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