Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.31 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.31 |
| ▸ | ITGAV | P06756 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.31 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.31 |
| ▸ | ITGAL | P20701 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10758827 | 1.00 | ALDH1A1 (0.37) | ALDH1A1PKMLMNATSHRMAP3K14 | |
| SCHEMBL785503 | 1.00 | ALDH1A1 (0.37) | ALDH1A1PKMLMNATSHRMAP3K14 | |
| SCHEMBL6685775 | 1.00 | ALDH1A1 (0.37) | ALDH1A1PKMLMNATSHRMAP3K14 | |
| SCHEMBL5560867 | 1.00 | ALDH1A1 (0.37) | ALDH1A1PKMLMNATSHRMAP3K14 | |
| SCHEMBL5560865 | 1.00 | ALDH1A1 (0.37) | ALDH1A1PKMLMNATSHRMAP3K14 | |
| SCHEMBL24311746 | 0.98 | MAPT (0.36) | ALDH1A1PKMLMNATSHRMAP3K14 | |
| SCHEMBL17974614 | 0.98 | MAPT (0.36) | ALDH1A1PKMLMNATSHRMAP3K14 | |
| SCHEMBL19671609 | 0.98 | MAPT (0.36) | ALDH1A1PKMLMNATSHRMAP3K14 | |
| SCHEMBL3738614 | 0.95 | — | — | |
| SCHEMBL22556208 | 0.95 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1354875-B1 | Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof; and use in the synthesis of perindopril | SERVIER LAB (FR) | 2004-11-24 | — | — | EP | disclosed |
| EP-1354875-A1 | Method for synthesis of (2S,3aS,7aS)-perhydroindole-2-carboxylic acid and esters thereof; and use in the synthesis of perindopril | Les Laboratoires Servier (FR) | 2003-10-22 | — | — | EP | disclosed |