Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.34 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.31 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.31 |
| ▸ | ITGAV | P06756 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.31 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.31 |
| ▸ | ITGAL | P20701 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10758827 | 1.00 | ALDH1A1 (0.37) | ALDH1A1PKMLMNATSHRMAP3K14 | |
| SCHEMBL785503 | 1.00 | ALDH1A1 (0.37) | ALDH1A1PKMLMNATSHRMAP3K14 | |
| SCHEMBL6685775 | 1.00 | ALDH1A1 (0.37) | ALDH1A1PKMLMNATSHRMAP3K14 | |
| SCHEMBL5560867 | 1.00 | ALDH1A1 (0.37) | ALDH1A1PKMLMNATSHRMAP3K14 | |
| SCHEMBL8450841 | 1.00 | ALDH1A1 (0.37) | ALDH1A1PKMLMNATSHRMAP3K14 | |
| SCHEMBL24311746 | 0.98 | MAPT (0.36) | ALDH1A1PKMLMNATSHRMAP3K14 | |
| SCHEMBL17974614 | 0.98 | MAPT (0.36) | ALDH1A1PKMLMNATSHRMAP3K14 | |
| SCHEMBL19671609 | 0.98 | MAPT (0.36) | ALDH1A1PKMLMNATSHRMAP3K14 | |
| SCHEMBL3738614 | 0.95 | — | — | |
| SCHEMBL22556208 | 0.95 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101597254-A | A kind of Trolapril intermediates preparation | SHANGHAI JINSHAN PHARMACEUTICA (CN) | 2009-12-09 | — | — | CN | claimed |
| US-20070225505-A1 | Method for the Preparation of (2S, 3AR, 7AS)-Octahydro-III-Indole-2-Carboxylic Acid as Key Intermediate in the Preparation of Trandolapril by Reacting a Cyclohexyl Aziridine with a Dialkyl Malonate | TEXCONTOR ETABLISSEMENT (LI) | 2007-09-27 | — | — | US | claimed |
| EP-1687271-A1 | A METHOD FOR THE PREPARATION OF (2S, 3AR, 7AS)-OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID AS KEY INTERMEDIATE IN THE PREPARATION OF TRANDOLAPRIL BY REACTING A CYCLOHEXYL AZIRIDINE WITH A DIALKYL MALONATE | Texcontor Etablissement (LI) | 2006-08-09 | — | — | EP | claimed |
| WO-2005054194-A1 | A METHOD FOR THE PREPARATION OF (2S, 3AR, 7AS)-OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID AS KEY INTERMEDIATE IN THE PREPARATION OF TRANDOLAPRIL BY REACTING A CYCLOHEXYL AZIRIDINE WITH A DIALKYL MALONATE | TEXCONTOR ETABLISSEMENT (LI) | 2005-06-16 | — | — | WO | claimed |
| CN-101597254-A | A kind of Trolapril intermediates preparation | SHANGHAI JINSHAN PHARMACEUTICA (CN) | 2009-12-09 | — | — | CN | disclosed |
| US-20070225505-A1 | Method for the Preparation of (2S, 3AR, 7AS)-Octahydro-III-Indole-2-Carboxylic Acid as Key Intermediate in the Preparation of Trandolapril by Reacting a Cyclohexyl Aziridine with a Dialkyl Malonate | TEXCONTOR ETABLISSEMENT (LI) | 2007-09-27 | — | — | US | disclosed |
| US-20070225505-A1 | Method for the Preparation of (2S, 3AR, 7AS)-Octahydro-III-Indole-2-Carboxylic Acid as Key Intermediate in the Preparation of Trandolapril by Reacting a Cyclohexyl Aziridine with a Dialkyl Malonate | TEXCONTOR ETABLISSEMENT (LI) | 2007-09-27 | — | — | US | disclosed |
| EP-1687271-A1 | A METHOD FOR THE PREPARATION OF (2S, 3AR, 7AS)-OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID AS KEY INTERMEDIATE IN THE PREPARATION OF TRANDOLAPRIL BY REACTING A CYCLOHEXYL AZIRIDINE WITH A DIALKYL MALONATE | Texcontor Etablissement (LI) | 2006-08-09 | — | — | EP | disclosed |
| EP-1687271-A1 | A METHOD FOR THE PREPARATION OF (2S, 3AR, 7AS)-OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID AS KEY INTERMEDIATE IN THE PREPARATION OF TRANDOLAPRIL BY REACTING A CYCLOHEXYL AZIRIDINE WITH A DIALKYL MALONATE | Texcontor Etablissement (LI) | 2006-08-09 | — | — | EP | disclosed |
| WO-2005054194-A1 | A METHOD FOR THE PREPARATION OF (2S, 3AR, 7AS)-OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID AS KEY INTERMEDIATE IN THE PREPARATION OF TRANDOLAPRIL BY REACTING A CYCLOHEXYL AZIRIDINE WITH A DIALKYL MALONATE | TEXCONTOR ETABLISSEMENT (LI) | 2005-06-16 | — | — | WO | disclosed |
| WO-2005054194-A1 | A METHOD FOR THE PREPARATION OF (2S, 3AR, 7AS)-OCTAHYDRO-1H-INDOLE-2-CARBOXYLIC ACID AS KEY INTERMEDIATE IN THE PREPARATION OF TRANDOLAPRIL BY REACTING A CYCLOHEXYL AZIRIDINE WITH A DIALKYL MALONATE | TEXCONTOR ETABLISSEMENT (LI) | 2005-06-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225505-A1 | Method for the Preparation of (2S, 3AR, 7AS)-Octahydro-III-Indole-2-Carboxylic Acid as Key Intermediate in the Preparation of Trandolapril by Reacting a Cyclohexyl Aziridine with a Dialkyl Malonate | IDO1, TPH1, AGTR1 | ALDH1A1 149/4885PKM 863/4885LMNA 2086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.