SCHEMBL8450867

SCHEMBL8450867

O=C1NN=C(c2cccc([N+](=O)[O-])c2)CO1

nearest known ligand 0.53

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PDE3B Q13370 19/20 0.53
PDE3A Q14432 19/20 0.53
MAPT P10636 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7979367 0.83 PDE3B (0.51) PDE3BPDE3AMAPT
SCHEMBL5560697 0.79 AXL (0.57) MAPT
SCHEMBL11715122 0.79 MAPT (0.49) MAPT
SCHEMBL11624623 0.78 SMN1; SMN2 (0.58) PDE3BPDE3AMAPT
SCHEMBL10803263 0.77 MAPT (0.50) MAPT
SCHEMBL10805138 0.74 PDE3B (0.62) PDE3BPDE3A
SCHEMBL20702701 0.73 PDE3B (0.86) PDE3BPDE3A
SCHEMBL22348268 0.70 SMN1; SMN2 (0.49) MAPT
SCHEMBL6738366 0.70 TSHR (0.76) MAPT
SCHEMBL27553481 0.69 MAPT (0.48) MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0601783-B1 Blowing agent concentrate GEN ELECTRIC (US) 1999-04-14 EP disclosed
EP-0601783-A1 Blowing agent concentrate GENERAL ELECTRIC COMPANY (US) 1994-06-15 EP disclosed
US-5272182-A Blowing agent concentrate and compositions and article prepared therefrom GENERAL ELECTRIC COMPANY (US) 1993-12-21 US disclosed
US-4334030-A INJECTION MOLDABLE CONCENTRATES CONTAINING AMIDE DERIVATIVES OF AZODICARBOXYLIC ACID AND A DIHYDROOXADIAZINONE AS BLOWING AGENTS GENERAL ELECTRIC COMPANY (US) 1982-06-08 US disclosed
US-4163037-A USING A DIHYDROOXADIAZINONE BLOWING AGENT, INJECTION MOLDING GENERAL ELECTRIC COMPANY (US) 1979-07-31 US disclosed
US-4097425-A POLYCARBONATES, POLYESTERS, SUBSTITUTED 3,6-DIHYDRO-1,3,4-OXDIAZIN-2-ONE GENERAL ELECTRIC COMPANY (US) 1978-06-27 US disclosed