Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | PGR | P06401 | 2/20 | 0.52 |
| ▸ | TDP2 | O95551 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GUSB | P08236 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11624623 | 0.87 | SMN1; SMN2 (0.58) | MAPTPGRTDP2LMNAALDH1A1 | |
| SCHEMBL5560748 | 0.81 | AXL (0.59) | AXLMAPTTDP2LMNAALDH1A1 | |
| SCHEMBL10803263 | 0.80 | MAPT (0.50) | MAPTPGRTDP2LMNAALDH1A1 | |
| SCHEMBL8450867 | 0.79 | PDE3B (0.53) | MAPT | |
| SCHEMBL27995075 | 0.76 | AXL (0.77) | AXLTDP2ALDH1A1SMN1; SMN2PSMB8 | |
| SCHEMBL1422939 | 0.75 | ALDH1A1 (0.65) | MAPTPGRTDP2ALDH1A1SMN1; SMN2 | |
| SCHEMBL2892328 | 0.74 | AXL (0.46) | AXLMAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL11624276 | 0.74 | GALR3 (0.67) | MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL2299377 | 0.74 | PGR (0.56) | MAPTPGRTDP2ALDH1A1MEN1 | |
| SCHEMBL22348268 | 0.73 | SMN1; SMN2 (0.49) | MAPTPGRTDP2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262201-B1 | For the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals | ASTRAZENECA AB (SE) | 2007-08-28 | — | — | US | disclosed |
| EP-1119567-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2001-08-01 | — | — | EP | disclosed |
| WO-2000021955-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2000-04-20 | — | — | WO | disclosed |