Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.54 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | PTPRC | P08575 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1459762 | 0.89 | ALDH1A1 (0.54) | ALDH1A1MAPTHTTHSP90AA1NPSR1 | |
| SCHEMBL11450534 | 0.85 | ALDH1A1 (0.49) | ALDH1A1MAPTHTTHSP90AA1NPSR1 | |
| SCHEMBL11443595 | 0.84 | ALDH1A1 (0.54) | ALDH1A1MAPTHTTHSP90AA1NPSR1 | |
| SCHEMBL28728423 | 0.81 | TSHR (0.67) | ALDH1A1MAPTHTTHSP90AA1NPSR1 | |
| SCHEMBL7911029 | 0.80 | ALDH1A1 (0.61) | ALDH1A1MAPTHTTHSP90AA1NPSR1 | |
| SCHEMBL11443850 | 0.79 | HAO1 (0.46) | MAPTHTTTSHRLMNA | |
| SCHEMBL1507602 | 0.78 | TSHR (0.57) | ALDH1A1MAPTHTTHSP90AA1NPSR1 | |
| SCHEMBL3874391 | 0.78 | ALDH1A1 (0.60) | ALDH1A1MAPTHTTHSP90AA1NPSR1 | |
| SCHEMBL29433452 | 0.78 | TSHR (0.57) | ALDH1A1MAPTHTTHSP90AA1NPSR1 | |
| SCHEMBL12632215 | 0.77 | FFAR1 (0.54) | ALDH1A1MAPTHTTHSP90AA1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4219679-A | HIGH CONVERSION | GULF RESEARCH & DEVELOPMENT COMPANY (US) | 1980-08-26 | — | — | US | claimed |
| US-4216341-A | Selective hydrogenation of certain nitroaromatic hydroxy substituted acetylenes over a heterogeneous RuS2 catalyst | GULF RESEARCH & DEVELOPMENT COMPANY (US) | 1980-08-05 | — | — | US | claimed |
| US-4204078-A | REACTING NITROBROMOBENZENE WITH A HYDROXY-ACETYLENE COMPOUND; AMINE SOLVENT AND PALLADIUM COMPLEX CATALYST | GULF RESEARCH & DEVELOPMENT COMPANY (US) | 1980-05-20 | — | — | US | claimed |
| EP-0001479-A2 | Process for the preparation of nitrophenylhydroxyacetylene and conversion to nitrophenylacetylene | GULF RESEARCH & DEVELOPMENT COMPANY (US) | 1979-04-18 | — | — | EP | claimed |
| US-4139561-A | RUTHENIUM HYDROGENATION CATALYST | GULF RESEARCH & DEVELOPMENT COMPANY (US) | 1979-02-13 | — | — | US | claimed |
| US-4128588-A | PALLADIUM-PHOSPHINE COMPLEX CATALYST | GULF RESEARCH & DEVELOPMENT COMPANY (US) | 1978-12-05 | — | — | US | claimed |
| WO-2023048034-A1 | METHOD FOR PRODUCING AROMATIC COMPOUND HAVING ETHYNYL GROUP | 東レ・ファインケミカル株式会社 | 2023-03-30 | — | — | WO | disclosed |
| WO-2023008401-A1 | METHOD FOR PRODUCING AROMATIC COMPOUND HAVING ETHYNYL GROUP | 東レ・ファインケミカル株式会社 | 2023-02-02 | — | — | WO | disclosed |
| EP-2433931-B2 | New method for the preparation of erlotinib | ITALIANA SINT SPA (IT) | 2016-11-02 | — | — | EP | disclosed |
| EP-2433931-B2 | New method for the preparation of erlotinib | ITALIANA SINT SPA (IT) | 2016-11-02 | — | — | EP | disclosed |
| US-8609841-B2 | Method for the preparation of erlotinib | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2013-12-17 | — | — | US | disclosed |
| EP-2433931-B1 | New method for the preparation of erlotinib | ITALIANA SINT SPA (IT) | 2013-08-21 | — | — | EP | disclosed |
| US-20120095228-A1 | METHOD FOR THE PREPARATION OF ERLOTINIB | F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. (IT) | 2012-04-19 | — | — | US | disclosed |
| WO-1999003803-A2 | PROCESS FOR PREPARING AMINOARYLACETYLENES | CATALYTICA PHARMACEUTICALS, INC. (US) | 1999-01-28 | — | — | WO | disclosed |
| US-4219679-A | HIGH CONVERSION | GULF RESEARCH & DEVELOPMENT COMPANY (US) | 1980-08-26 | — | — | US | disclosed |
| US-4216341-A | Selective hydrogenation of certain nitroaromatic hydroxy substituted acetylenes over a heterogeneous RuS2 catalyst | GULF RESEARCH & DEVELOPMENT COMPANY (US) | 1980-08-05 | — | — | US | disclosed |
| US-4204078-A | REACTING NITROBROMOBENZENE WITH A HYDROXY-ACETYLENE COMPOUND; AMINE SOLVENT AND PALLADIUM COMPLEX CATALYST | GULF RESEARCH & DEVELOPMENT COMPANY (US) | 1980-05-20 | — | — | US | disclosed |
| EP-0001479-A2 | Process for the preparation of nitrophenylhydroxyacetylene and conversion to nitrophenylacetylene | GULF RESEARCH & DEVELOPMENT COMPANY (US) | 1979-04-18 | — | — | EP | disclosed |
| US-4139561-A | RUTHENIUM HYDROGENATION CATALYST | GULF RESEARCH & DEVELOPMENT COMPANY (US) | 1979-02-13 | — | — | US | disclosed |
| US-4128588-A | PALLADIUM-PHOSPHINE COMPLEX CATALYST | GULF RESEARCH & DEVELOPMENT COMPANY (US) | 1978-12-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095228-A1 | METHOD FOR THE PREPARATION OF ERLOTINIB | EGFR, ABL1, ERBB2 | ALDH1A1 823/4885MAPT 2264/4885HTT 4538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.