Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTR1B | P28222 | 7/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7333407 | 0.83 | KDM4E (0.41) | KDM4EALDH1A1HTR1BHPGDATM | |
| SCHEMBL7343282 | 0.81 | KCNH2 (0.39) | KDM4EALDH1A1HPGDATMMEN1 | |
| SCHEMBL7337149 | 0.79 | DRD2 (0.44) | KDM4EALDH1A1HTR1BHPGDATM | |
| SCHEMBL8344355 | 0.79 | DRD2 (0.43) | KDM4EALDH1A1HTR1BHPGDATM | |
| SCHEMBL17513639 | 0.71 | METAP2 (0.44) | HDAC1HDAC6NPSR1 | |
| SCHEMBL16899094 | 0.69 | METAP2 (0.44) | HDAC1HDAC6 | |
| SCHEMBL16899167 | 0.67 | METAP2 (0.45) | HDAC1HDAC6 | |
| SCHEMBL7334771 | 0.66 | KDM4E (0.42) | KDM4EALDH1A1HTR1BHTR1DL3MBTL1 | |
| SCHEMBL16899264 | 0.65 | MC4R (0.42) | KMT2AHDAC1HDAC6 | |
| SCHEMBL11374514 | 0.65 | KDM4E (0.47) | KDM4EALDH1A1HTR1BHPGDATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0964854-A1 | 4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-THIONES DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-12-22 | — | — | EP | disclosed |
| WO-1998035947-A1 | 4-AMINOALKOXY-1,3-DIHYDROBENZOIMIDAZOL-2-THIONES DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DOPAMINE AUTORECEPTOR (D2) AGONISTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-08-20 | — | — | WO | disclosed |