Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3589258 | 0.82 | KMT2A (0.43) | ALDH1A1LMNACHRM2OPRM1DDB1 | |
| Hydrochloric Acid SCHEMBL3593448 | 0.82 | KMT2A (0.43) | ALDH1A1LMNAMAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL4103132 | 0.78 | DDB1 (0.50) | ALDH1A1CHRM2OPRM1DDB1CRBN | |
| SCHEMBL2919642 | 0.78 | CRBN (0.50) | ALDH1A1CHRM2OPRM1DDB1CRBN | |
| SCHEMBL3366426 | 0.77 | ALDH1A1 (0.56) | ALDH1A1CA1CA2ALDH3A1LMNA | |
| SCHEMBL26489650 | 0.77 | ALDH1A1 (0.69) | ALDH1A1CA1CA2ALDH3A1LMNA | |
| SCHEMBL4929916 | 0.76 | CRBN (0.48) | ALDH1A1CHRM2OPRM1DDB1CRBN | |
| SCHEMBL4120260 | 0.76 | ALDH1A1 (0.50) | ALDH1A1ALDH3A1CHRM2OPRM1DDB1 | |
| SCHEMBL24921833 | 0.75 | ALDH1A1 (0.38) | ALDH1A1CHRM2OPRM1DDB1CRBN | |
| SCHEMBL4119644 | 0.74 | CASP3 (0.49) | ALDH1A1CA2LMNACHRM2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3915556-A1 | RECTAL APPLICATION OF THALIDOMIDE IN PATIENTS WITH HEMORRHAGIC CHRONIC RADIATION PROCTITIS | Vonnahme, Franz Josef (DE) | 2021-12-01 | — | — | EP | disclosed |
| US-8143283-B1 | Methods for treating blood-born tumors with thalidomide | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2012-03-27 | — | — | US | disclosed |
| US-7723361-B2 | Methods for inhibiting undesired angiogenesis in patients having tumors with thalidomide | CELGENE CORPORATION (US) | 2010-05-25 | — | — | US | disclosed |