⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3060656 | 0.65 | CRBN (0.34) | — | |
| SCHEMBL12748060 | 0.64 | — | — | |
| SCHEMBL407513 | 0.63 | BLM (0.42) | — | |
| SCHEMBL12384203 | 0.63 | — | — | |
| SCHEMBL18671722 | 0.61 | — | — | |
| SCHEMBL31319116 | 0.61 | ALDH1A1 (0.36) | — | |
| SCHEMBL31319117 | 0.61 | ALDH1A1 (0.36) | — | |
| SCHEMBL12305806 | 0.59 | — | — | |
| SCHEMBL10765843 | 0.59 | — | — | |
| SCHEMBL19721811 | 0.59 | CRBN (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3915556-A1 | RECTAL APPLICATION OF THALIDOMIDE IN PATIENTS WITH HEMORRHAGIC CHRONIC RADIATION PROCTITIS | Vonnahme, Franz Josef (DE) | 2021-12-01 | — | — | EP | disclosed |
| US-20120142734-A1 | METHODS FOR TREATING TUMORS WITH THALIDOMIDE | THE CHILDREN'S MEDICAL CENTER CORPORATION | 2012-06-07 | — | — | US | disclosed |
| US-8143283-B1 | Methods for treating blood-born tumors with thalidomide | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2012-03-27 | — | — | US | disclosed |
| US-7723361-B2 | Methods for inhibiting undesired angiogenesis in patients having tumors with thalidomide | CELGENE CORPORATION (US) | 2010-05-25 | — | — | US | disclosed |