Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | RHOC | P08134 | 1/20 | 0.43 |
| ▸ | RHOA | P61586 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PREP | P48147 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845229 | 0.93 | RHOC (0.48) | ALDH1A1LMNARHOCRHOANPC1 | |
| SCHEMBL13272503 | 0.88 | LMNA (0.36) | ALDH1A1LMNARHOCRHOANPC1 | |
| SCHEMBL845599 | 0.87 | RHOC (0.43) | ALDH1A1LMNARHOCRHOANPC1 | |
| SCHEMBL844961 | 0.86 | RHOC (0.43) | ALDH1A1LMNARHOCRHOANPC1 | |
| SCHEMBL845255 | 0.86 | CYP2C9 (0.47) | ALDH1A1LMNARHOCRHOANPC1 | |
| SCHEMBL845478 | 0.84 | NPC1 (0.43) | ALDH1A1LMNARHOCRHOANPC1 | |
| SCHEMBL844884 | 0.82 | HTT (0.48) | ALDH1A1LMNARHOCRHOANPC1 | |
| SCHEMBL845234 | 0.81 | RHOC (0.43) | ALDH1A1LMNARHOCRHOANPC1 | |
| SCHEMBL27006226 | 0.80 | RHOC (0.51) | ALDH1A1RHOCRHOANPC1ROCK2 | |
| SCHEMBL27012630 | 0.80 | RHOC (0.51) | ALDH1A1RHOCRHOANPC1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| EP-1893573-B1 | INHIBITORS OF HCV REPLICATION | BRISTOL MYERS SQUIBB CO (US) | 2010-07-21 | — | — | EP | disclosed |