Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845451 | 0.96 | POLB (0.57) | POLBLMNAKDM4EKDM1ARCOR1 | |
| SCHEMBL845136 | 0.89 | POLB (0.59) | POLBLMNAKDM4EKDM1ARCOR1 | |
| SCHEMBL845261 | 0.84 | POLB (0.56) | POLBLMNAKDM4EKDM1ARCOR1 | |
| SCHEMBL845487 | 0.84 | POLB (0.56) | POLBLMNAKDM4EKDM1ARCOR1 | |
| SCHEMBL845529 | 0.84 | POLB (0.56) | POLBLMNAKDM4EKDM1ARCOR1 | |
| SCHEMBL845689 | 0.84 | POLB (0.58) | POLBLMNAKDM4EKDM1ARCOR1 | |
| SCHEMBL845254 | 0.84 | POLB (0.58) | POLBLMNAKDM4EKDM1ARCOR1 | |
| SCHEMBL844855 | 0.84 | POLB (0.58) | POLBLMNAKDM4EKDM1ARCOR1 | |
| SCHEMBL872849 | 0.83 | POLB (0.49) | POLBKDM4EHSD17B10CCNE1CDK2 | |
| SCHEMBL845654 | 0.82 | POLB (0.59) | POLBLMNAKDM4EKDM1ARCOR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |