Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 7/20 | 0.35 |
| ▸ | NPC1 | O15118 | 6/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.33 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | MMP9 | P14780 | 2/20 | 0.33 |
| ▸ | MMP8 | P22894 | 2/20 | 0.33 |
| ▸ | MMP13 | P45452 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845451 | 0.88 | POLB (0.57) | POLBKMT2AMEN1L3MBTL1CASP1 | |
| SCHEMBL845455 | 0.83 | POLB (0.50) | POLBKMT2AMEN1L3MBTL1HSD17B10 | |
| SCHEMBL845136 | 0.80 | POLB (0.59) | POLBKMT2AMEN1L3MBTL1CASP1 | |
| SCHEMBL845654 | 0.74 | POLB (0.59) | POLBKMT2AMEN1L3MBTL1MMP2 | |
| SCHEMBL13272182 | 0.73 | LMNA (0.49) | POLBKMT2AMEN1NPC1L3MBTL1 | |
| SCHEMBL845105 | 0.72 | POLB (0.56) | POLBKMT2AMEN1HSD17B10ALDH1A1 | |
| SCHEMBL845132 | 0.70 | POLB (0.72) | POLBKMT2AMEN1L3MBTL1APOBEC3A | |
| SCHEMBL844848 | 0.70 | POLB (0.72) | POLBKMT2AMEN1L3MBTL1APOBEC3A | |
| SCHEMBL845357 | 0.70 | POLB (0.72) | POLBKMT2AMEN1L3MBTL1APOBEC3A | |
| SCHEMBL845261 | 0.67 | POLB (0.56) | POLBKMT2AMEN1L3MBTL1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |