Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SGMS2 | Q8NHU3 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | APP | P05067 | 5/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL845473 | 0.91 | HSD17B10 (0.47) | HSD17B10KDM4ELMNAKDM1ARCOR1 | |
| SCHEMBL845353 | 0.88 | KDM4E (0.52) | GAAHSD17B10KDM4ELMNAAPP | |
| SCHEMBL845005 | 0.88 | KDM4E (0.54) | SGMS2GAAHSD17B10KDM4ELMNA | |
| SCHEMBL13272444 | 0.86 | ALDH1A1 (0.56) | HSD17B10KDM4ELMNAKDM1ARCOR1 | |
| SCHEMBL845111 | 0.86 | ALDH1A1 (0.56) | HSD17B10KDM4ELMNAKDM1ARCOR1 | |
| SCHEMBL1030175 | 0.86 | ALDH1A1 (0.56) | HSD17B10KDM4ELMNAKDM1ARCOR1 | |
| SCHEMBL15116912 | 0.86 | ALDH1A1 (0.56) | HSD17B10KDM4ELMNAKDM1ARCOR1 | |
| SCHEMBL845205 | 0.86 | ALDH1A1 (0.56) | HSD17B10KDM4ELMNAKDM1ARCOR1 | |
| SCHEMBL845226 | 0.86 | ALDH1A1 (0.56) | HSD17B10KDM4ELMNAKDM1ARCOR1 | |
| SCHEMBL845484 | 0.85 | ALDH1A1 (0.48) | HSD17B10KDM4ELMNAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| EP-1893573-B1 | INHIBITORS OF HCV REPLICATION | BRISTOL MYERS SQUIBB CO (US) | 2010-07-21 | — | — | EP | disclosed |