Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | KDM1A | O60341 | 1/20 | 0.50 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 5/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.47 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873465 | 0.92 | KDM4E (0.47) | KDM4ELMNAHSD17B10NPSR1KDM1A | |
| SCHEMBL845312 | 0.89 | GAA (0.60) | KDM4ELMNATSHRL3MBTL1ALDH1A1 | |
| SCHEMBL845503 | 0.88 | SGMS2 (0.52) | KDM4ELMNAHSD17B10NPSR1KDM1A | |
| SCHEMBL845060 | 0.87 | KDM4E (0.51) | KDM4ELMNAHSD17B10NPSR1KDM1A | |
| SCHEMBL845518 | 0.87 | GAA (0.52) | KDM4ELMNATSHRL3MBTL1ALDH1A1 | |
| SCHEMBL845021 | 0.86 | ALDH1A1 (0.53) | KDM4ELMNANPSR1TSHRALDH1A1 | |
| SCHEMBL845284 | 0.85 | MAPK1 (0.58) | LMNANPSR1ALDH1A1GAAPABPC1 | |
| SCHEMBL845353 | 0.85 | KDM4E (0.52) | KDM4ELMNAHSD17B10NPSR1KDM1A | |
| SCHEMBL845392 | 0.83 | ALDH1A1 (0.51) | KDM4ELMNAHSD17B10KDM1ARCOR1 | |
| SCHEMBL845355 | 0.83 | ALDH1A1 (0.50) | KDM4ELMNAHSD17B10KDM1ARCOR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| EP-1893573-B1 | INHIBITORS OF HCV REPLICATION | BRISTOL MYERS SQUIBB CO (US) | 2010-07-21 | — | — | EP | disclosed |