Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.59 |
| ▸ | KDM1A | O60341 | 1/20 | 0.57 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL844848 | 0.89 | POLB (0.72) | POLBKDM1ARCOR1KDM4ELMNA | |
| SCHEMBL845357 | 0.89 | POLB (0.72) | POLBKDM1ARCOR1KDM4ELMNA | |
| SCHEMBL845132 | 0.89 | POLB (0.72) | POLBKDM1ARCOR1KDM4ELMNA | |
| SCHEMBL845165 | 0.88 | KDM4E (0.55) | POLBKDM1ARCOR1KDM4ELMNA | |
| SCHEMBL845151 | 0.88 | ALDH1A1 (0.48) | POLBKDM1ARCOR1KDM4ELMNA | |
| SCHEMBL845252 | 0.86 | KDM4E (0.73) | KDM1ARCOR1KDM4ELMNAHSD17B10 | |
| SCHEMBL844832 | 0.86 | KDM4E (0.73) | KDM1ARCOR1KDM4ELMNAHSD17B10 | |
| SCHEMBL845226 | 0.85 | ALDH1A1 (0.56) | KDM1ARCOR1KDM4ELMNAHSD17B10 | |
| SCHEMBL15116912 | 0.85 | ALDH1A1 (0.56) | KDM1ARCOR1KDM4ELMNAHSD17B10 | |
| SCHEMBL845111 | 0.85 | ALDH1A1 (0.56) | KDM1ARCOR1KDM4ELMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |