SCHEMBL8455442

SCHEMBL8455442

CCCCCCC[SiH]1CCC(c2ccc(OCC(F)F)cc2)CC1

nearest known ligand 0.42

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.36
RAB9A P51151 1/20 0.36
SPHK1 Q9NYA1 3/20 0.36
MAOA P21397 1/20 0.36
MAOB P27338 1/20 0.36
CRBN Q96SW2 1/20 0.36
S1PR3 Q99500 1/20 0.35
NPC1 O15118 1/20 0.34
CYP2C9 P11712 1/20 0.34
HRH3 Q9Y5N1 1/20 0.34
PLA2G4B P0C869 1/20 0.33
DRD2 P14416 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8455445 1.00 LMNA (0.36) LMNARAB9ASPHK1MAOAMAOB
SCHEMBL9002307 0.95 LMNA (0.35) LMNARAB9ASPHK1MAOAMAOB
SCHEMBL9002301 0.95 LMNA (0.35) LMNARAB9ASPHK1MAOAMAOB
SCHEMBL7767580 0.89 RAB9A (0.35) LMNARAB9ASPHK1MAOAMAOB
SCHEMBL7767582 0.89 RAB9A (0.35) LMNARAB9ASPHK1MAOAMAOB
SCHEMBL7767581 0.89 RAB9A (0.35) LMNARAB9ASPHK1MAOAMAOB
SCHEMBL8581161 0.88 P2RY14 (0.35) LMNARAB9ASPHK1CRBNS1PR3
SCHEMBL8581162 0.88 P2RY14 (0.35) LMNARAB9ASPHK1CRBNS1PR3
SCHEMBL8581166 0.88 P2RY14 (0.35) LMNARAB9ASPHK1CRBNS1PR3
SCHEMBL8451932 0.83 KDM1A (0.37) SPHK1S1PR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6004478-A LIQUID CRYSTAL SHIN-ETSU CHEMICAL CO., LTD. (JP) 1999-12-21 US disclosed
EP-0732335-A1 Novel silacyclohexane compounds, preparation thereof, liquid crystal compositions comprising the same, and liquid crystal devices comprising the composition SHIN-ETSU CHEMICAL CO., LTD. (JP) 1996-09-18 EP disclosed