Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21661644 | 0.84 | SMN1; SMN2 (0.35) | ATMMEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL15188004 | 0.77 | LMNA (0.46) | ATMALDH1A1LMNA | |
| SCHEMBL12102740 | 0.77 | LMNA (0.46) | ATMALDH1A1LMNA | |
| SCHEMBL25474851 | 0.77 | ATM (0.37) | ATMLMNASMN1; SMN2 | |
| SCHEMBL11977462 | 0.77 | LMNA (0.46) | ATMALDH1A1LMNA | |
| SCHEMBL25474849 | 0.77 | ATM (0.37) | ATMLMNASMN1; SMN2 | |
| SCHEMBL15504586 | 0.77 | ATM (0.37) | ATMLMNASMN1; SMN2 | |
| SCHEMBL21777478 | 0.76 | FAAH (0.38) | MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL25144026 | 0.76 | ATM (0.36) | ATMLMNASMN1; SMN2 | |
| SCHEMBL25144018 | 0.76 | ATM (0.36) | ATMLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432555-A1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | Incyte Corporation (US) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010135650-A1 | N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2010-11-25 | — | — | WO | disclosed |