Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | FDPS | P14324 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8735897 | 0.88 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1FDPSCYP1A2 | |
| SCHEMBL8457131 | 0.80 | TSHR (0.49) | SMN1; SMN2ALDH1A1TSHRPOLB | |
| SCHEMBL18163286 | 0.78 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL8459392 | 0.77 | TSHR (0.42) | SMN1; SMN2ALDH1A1TSHRKMT2AFDPS | |
| SCHEMBL8154438 | 0.77 | TSHR (0.49) | SMN1; SMN2ALDH1A1TSHRPOLB | |
| SCHEMBL8159050 | 0.76 | TSHR (0.48) | SMN1; SMN2ALDH1A1TSHRPOLB | |
| SCHEMBL6643882 | 0.75 | SMN1; SMN2 (0.55) | SMN1; SMN2ALDH1A1HPGDHDAC6HDAC1 | |
| SCHEMBL2769178 | 0.74 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1TSHRMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL2769175 | 0.73 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL8459534 | 0.72 | CA12 (0.47) | SMN1; SMN2ALDH1A1TSHRHDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5880112-A | PHOSPHINIC ACID DERIVATIVES; PROSTATE CANCER TREATMENT | GUILFORD PHARMACEUTICALS INC. (US) | 1999-03-09 | — | — | US | disclosed |
| US-5804602-A | N-ACETYLATED ALPHA-LINKED ACIDIC DIPEPTIDASE INHIBITORS | GUILFORD PHARMACEUTICALS INC. (US) | 1998-09-08 | — | — | US | disclosed |
| US-5672592-A | HYDROLASE INHIBITORS, ANTITUMOR AND ANTICARCINOGENIC AGENTS, FOR PROSTATE CANCER | GUILFORD PHARMACEUTICALS INC. (US) | 1997-09-30 | — | — | US | disclosed |