Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.52 |
| ▸ | PPARG | P37231 | 5/20 | 0.51 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.51 |
| ▸ | MPC2 | O95563 | 1/20 | 0.50 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8981902 | 0.90 | DNMT3A (0.64) | DNMT3AHDAC1HDAC6NLRP3 | |
| SCHEMBL8981982 | 0.88 | DNMT3A (0.57) | DNMT3ALMNAHDAC1HDAC6NLRP3 | |
| SCHEMBL8981978 | 0.88 | DNMT3A (0.57) | DNMT3ALMNAHDAC1HDAC6NLRP3 | |
| SCHEMBL8981980 | 0.88 | DNMT3A (0.57) | DNMT3ALMNAHDAC1HDAC6NLRP3 | |
| SCHEMBL8981845 | 0.88 | LMNA (0.52) | PPARGDNMT3ALMNAMAPTHPGD | |
| SCHEMBL8981831 | 0.88 | LMNA (0.52) | PPARGDNMT3ALMNAMAPTHPGD | |
| SCHEMBL8981839 | 0.88 | LMNA (0.52) | PPARGDNMT3ALMNAMAPTHPGD | |
| SCHEMBL8981741 | 0.85 | LMNA (0.49) | FFAR1PPARGDNMT3AMPC2CYP2C8 | |
| SCHEMBL8981737 | 0.85 | LMNA (0.49) | FFAR1PPARGDNMT3AMPC2CYP2C8 | |
| SCHEMBL8981731 | 0.85 | LMNA (0.49) | FFAR1PPARGDNMT3AMPC2CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999059586-A1 | THIAZOLIDINE AND OXAZOLIDINE DERIVATIVES FOR THE TREATMENT OF ACUTE MYOCARDIAL INFARCTION AND INHIBITION OF CARDIOMYOCYTE APOPTOSIS | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-11-25 | — | — | WO | claimed |
| US-5478851-A | Hyperglycemic agent and antilipemic agent | BEECHAM GROUP PLC (GB) | 1995-12-26 | — | — | US | claimed |
| EP-0555264-A1 | NOVEL COMPOUNDS | BEECHAM GROUP plc (GB) | 1993-08-18 | — | — | EP | claimed |
| WO-1992007850-A1 | NOVEL COMPOUNDS | BEECHAM GROUP PLC (GB) | 1992-05-14 | — | — | WO | claimed |
| WO-1999059586-A1 | THIAZOLIDINE AND OXAZOLIDINE DERIVATIVES FOR THE TREATMENT OF ACUTE MYOCARDIAL INFARCTION AND INHIBITION OF CARDIOMYOCYTE APOPTOSIS | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-11-25 | — | — | WO | disclosed |
| US-5478851-A | Hyperglycemic agent and antilipemic agent | BEECHAM GROUP PLC (GB) | 1995-12-26 | — | — | US | disclosed |